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Notch Signaling and the Skeleton
Abstract
Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch signaling plays an important role in skeletal development and bone remodeling. After direct interactions with ligands of the Jagged and Delta-like families, a series of cleavages release the Notch intracellular domain (NICD), which translocates to the nucleus where it induces transcription of Notch target genes. Classic gene targets of Notch are hairy and...
Paper Details
Title
Notch Signaling and the Skeleton
Published Date
Apr 13, 2016
Journal
Volume
37
Issue
3
Pages
223 - 253
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