Physicochemical and Functional Characterization of the Collagen–Polyvinylpyrrolidone Copolymer

Collagen–polyvinylpyrrolidone (C–PVP) is a copolymer that is generated from the γ irradiation of a mixture of type I collagen and low-molecular-weight PVP. It is characterized by immunomodulatory, fibrolytic, and antifibrotic properties. Here, we used various physicochemical and biological strategies to characterize the structure, biochemical susceptibility, as well as its effects on metabolic activity in fibroblasts. C–PVP contained 16 times...