Classical dendritic cells are required for dietary antigen–mediated induction of peripheral Treg cells and tolerance
Abstract
Oral tolerance prevents pathological inflammatory responses to innocuous foreign antigens by peripheral regulatory T cells (pT(reg) cells). However, whether a particular subset of antigen-presenting cells (APCs) is required during dietary antigen exposure for the 'instruction' of naive CD4(+) T cells to differentiate into pT(reg) cells has not been defined. Using myeloid lineage-specific APC depletion in mice, we found that monocyte-derived APCs...
Paper Details
Title
Classical dendritic cells are required for dietary antigen–mediated induction of peripheral Treg cells and tolerance
Published Date
Mar 28, 2016
Journal
Volume
17
Issue
5
Pages
545 - 555
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