Original paper
Classical dendritic cells are required for dietary antigen–mediated induction of peripheral Treg cells and tolerance
Abstract
Oral tolerance prevents pathological inflammatory responses to innocuous foreign antigens by peripheral regulatory T cells (pT(reg) cells). However, whether a particular subset of antigen-presenting cells (APCs) is required during dietary antigen exposure for the 'instruction' of naive CD4(+) T cells to differentiate into pT(reg) cells has not been defined. Using myeloid lineage-specific APC depletion in mice, we found that monocyte-derived APCs...
Paper Details
Title
Classical dendritic cells are required for dietary antigen–mediated induction of peripheral Treg cells and tolerance
Published Date
Mar 28, 2016
Journal
Volume
17
Issue
5
Pages
545 - 555
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Notes
History