Epidural Cortical Stimulation of the Left DLPFC Leads to Dose-Dependent Enhancement of Working Memory in Patients with MDD

Cognitive deficits are common across neuropsychiatric disorders, and a primary cause of functional disability. Nevertheless, clinicians have limited therapeutic options to facilitate cognitive enhancement, particularly of executive functions. We present results from a multicenter clinical trial of epidural cortical stimulation in patients with Major Depressive Disorder (MDD). The initial dose determination algorithm revealed acute dose-dependent...