Original paper
CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production
Abstract
Muscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axis that guides phagocyte infiltration is incompletely understood. Here, we show that CX3CR1 deficiency promotes muscle repair and rescues Ccl2(-/-) mice from impaired muscle regeneration as a result of altered macrophage function, not infiltration. Transcriptomic...
Paper Details
Title
CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production
Published Date
Dec 3, 2015
Journal
Volume
6
Issue
1
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Notes
History