A randomized placebo controlled trial of endomyocardial implantation of autologous bone marrow mononuclear cells in advanced ischemic Heart Failure (END-HF)

Aims: Prior studies suggest that autologous bone marrow mononuclear cells (BMCs) implantation improve symptoms and left ventricular (LV) function in patients (pts) with ischemic cardiomyopathy. However, the efficacy of endomyocardial implantation of BMCs in pts with advanced heart failure (HF) is unclear. Methods and results: We performed a randomized; double blinded and placebo-controlled trial in 28 pts with advanced ischemic HF (New York...