Assessing Therapy Response of Secreting Pineal Germ Cell Tumor on Simultaneous 18F-Choline PET/MRI

Published on Sep 1, 2014in Clinical Nuclear Medicine6.587
· DOI :10.1097/RLU.0000000000000231
Emmanouil Panagiotidis7
Estimated H-index: 7
Ananth Shankar14
Estimated H-index: 14
+ 1 AuthorsJamshed Bomanji52
Estimated H-index: 52
AbstractAn 18-year-old man presented with 6 weeks’ history of diplopia, early morning headaches, and blurred vision; on ophthalmologic examination, Parinaud syndrome was revealed. Brain MRI scan showed a calcified pineal mass. Brain simultaneous PET/MRI with 18F-choline showed an avid enhancing mass
#1Matthias Eiber (TUM: Technische Universität München)H-Index: 55
#2Axel Martinez-Möller (TUM: Technische Universität München)H-Index: 15
Last. Ambros J. Beer (TUM: Technische Universität München)H-Index: 51
view all 12 authors...
Purpose In this study, the potential contribution of Dixon-based MR imaging with a rapid low-resolution breath-hold sequence, which is a technique used for MR-based attenuation correction (AC) for MR/positron emission tomography (PET), was evaluated for anatomical correlation of PET-positive lesions on a 3T clinical scanner compared to low-dose CT. This technique is also used in a recently installed fully integrated whole-body MR/PET system.
152 CitationsSource
#1Sandi A. KweeH-Index: 20
#2Jehoon P. KoH-Index: 5
Last. Marc N. CoelH-Index: 20
view all 5 authors...
Purpose: To prospectively determine whether differences between benign and malignant brain lesions can be depicted with fluorine 18 (18F) fluorocholine positron emission tomography (PET). Materials and Methods: Thirty consecutive patients (14 women, 16 men; age range, 26–79 years) with solitary brain lesions that were enhanced at magnetic resonance (MR) imaging underwent whole-brain 18F-fluorocholine PET after giving informed consent in this institutional review board–approved, HIPAA-compliant s...
68 CitationsSource
#1Nicolas SpaethH-Index: 4
#2Matthias T. Wyss (MPG: Max Planck Society)H-Index: 33
Last. Alfred BuckH-Index: 62
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Differentiation between posttherapy radiation necrosis and recurrent tumor in humans with brain tumor is still a difficult diagnostic task. The new PET tracers (18)F-fluoro-ethyl-l-tyrosine (FET) and (18)F-fluorocholine (N,N-dimethyl-N-(18)F-fluoromethyl-2-hydroxyethylammonium [FCH]) have shown promise for improving diagnostic accuracy. This study assessed uptake of these tracers in experimental radiation injury. METHODS: In a first model, circumscribed lesions were induced in the cortex of 35 r...
93 Citations
#1Sandi A. Kwee (The Queen's Medical Center)H-Index: 20
#2Marc N. Coel (The Queen's Medical Center)H-Index: 20
Last. Jehoon P. Ko (The Queen's Medical Center)H-Index: 5
view all 4 authors...
Background. Choline metabolism is often abnormal in malignant brain tumors.Methods. Brain positron emission tomography (PET) imaging with F-18 fluorocholine (FCH) was performed on 2 patients with intracranial lesions suspected to be high-grade malignant gliomas on the basis of magnetic resonance (MR) imaging and multivoxel 1H-MR spectroscopic imaging (MRSI) findings. Standardized uptake value (SUV) measurements on PET were compared with measurements of choline/creatine metabolite ratio on MRSI i...
49 CitationsSource
#1Hans-Joachim Schmoll (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 71
Germ cell cancer is the most common malignancy in men aged 15–35 years; 5% of the malignant germ cell tumors are of extragonadal origin [1]. An extragonadal germ cell tumor (EGGCT) is by definition a germ cell neoplasm displaying one of the histologies associated with gonadal origin, but located outside of the gonads. This specific clinical entity was first described in the 19th century [2, 3]. Histological, serological and cytogenetic characteristics of EGGCTs are similar to those of primary te...
83 CitationsSource
Abstract This review summarizes the result of the distribution studies of 11 C-choline (CH) and 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG) using positron emission tomography (PET) in many patients with various tumors. The procedures were as follows: CH-PET, following transmission scan, emission scan started forty minutes after injection of CH: FDG-PET, following transmission scan, emission scan started forty minutes after injection of FDG. The final images were displayed on a scale of standardized ...
78 CitationsSource
Although considerable progress has been made using 18F-FDG in PET oncologic imaging, there are some well-known limitations to its use. These include the inability of FDG to visualize very small tumors, to visualize brain tumors and intrapelvic tumors, and to differentiate between malignancy and
62 Citations
#1Franca Podo (ISS: Istituto Superiore di Sanità)H-Index: 45
Summary in phospholipid metabolism represent major hallmarks of cancer cells. Changes in the MRS profiles of aqueous precursors and catabolites of phosphatidylcholine (PtdCho) in cancer lesions allow non invasive monitoring of tumor progression and response to conventional and targeted anti-cancer therapies. Advances and limitations of our present understanding of molecular mechanisms underlying these anomalous metabolic profiles will be here discussed in the light of altered expression and acti...
493 CitationsSource
Cited By5
#1Manfred Westphal (UHH: University of Hamburg)H-Index: 82
Tumors of the pineal region include a broad spectrum of histological entities which originate either from the pineal tissue matrix (pineal parenchymal tumors) or from local tissues in that area. Also, germinomatous tumors prefer that location so that this very small anatomical region with its lesions needs interdisciplinary approaches. Hydrocephalus is the main presenting symptom and needs urgent treatment, currently mostly by endoscopic ventriculostomy which also allows in some cases to take a ...
#1Ephraim E. Parent (Emory University)H-Index: 10
#1Ephraim E. Parent (Emory University)H-Index: 3
Last. Jonathan McConathy (UAB: University of Alabama at Birmingham)H-Index: 25
view all 2 authors...
Positron-emission tomography (PET) is a cross-sectional imaging technique that uses compounds labeled with positron-emitting radionuclides to measure the concentration and location of the radiolabeled compounds over time. PET has been used for a broad range of biomedical research and is used routinely in clinical patient care for oncologic, neurologic, and cardiac applications. PET has several properties that make this technique particularly well-suited for metabolic imaging as well as some impo...
#1Nathalie Testart Dardel (UGR: University of Granada)H-Index: 2
#2Manuel Gómez-RíoH-Index: 21
Last. Jose M. Llamas-ElviraH-Index: 18
view all 4 authors...
Purpose The purpose of this study is to conduct a systematic review of the published data about the current indications in clinical practice for the use of positron emission tomography (PET) or PET/computed tomography (PET/CT) using either Carbon-11 (11C) or Fluorine-18 (18F) choline tracer in brain tumours.
5 CitationsSource
#2Eric O. Aboagye (Imperial College London)H-Index: 50
Cancer cells do reprogramme their energy metabolism to enable several functions such as generation of biomass including membrane biosynthesis, and overcoming bioenergetic and redox stress. In this article we review both established and evolving radioprobes developed in association with positron emission tomography (PET) to detect tumor cell metabolism and effect of treatment. Measurement of enhanced tumor cell glycolysis using 2-deoxy-2-[18F]-fluoro-D-glucose is well established in the clinic. A...
33 CitationsSource
#1Dale L. Bailey (USYD: University of Sydney)H-Index: 60
#2Gerald AntochH-Index: 69
Last. Thomas BeyerH-Index: 58
view all 27 authors...
This paper summarises the proceedings and discussions at the third annual workshop held in Tubingen, Germany, dedicated to the advancement of the technical, scientific and clinical applications of combined PET/MRI systems in humans. Two days of basic scientific and technical instructions with “hands-on” tutorials were followed by 3 days of invited presentations from active researchers in this and associated fields augmented by round-table discussions and dialogue boards with specific themes. The...
42 CitationsSource