Ananth Shankar
University College Hospital
CancerInternal medicineRadiologySurgeryPathologyMagnetic resonance imagingOncologyRetrospective cohort studyStage (cooking)PediatricsYoung adultPositron emission tomographyChemotherapyGliomaLymphoma18F-cholineNodular Lymphocyte Predominant Hodgkin LymphomaNuclear medicineHodgkin lymphomaRadiation therapyEffective diffusion coefficientMedicine
62Publications
14H-index
742Citations
Publications 57
Newest
#1Margaret Olabisi Ogunbiyi (UCLH: University College London Hospitals NHS Foundation Trust)
Last. Ananth ShankarH-Index: 14
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Neuroblastoma-associated renal cell carcinoma (RCC) is a very rare subtype of renal neoplasia and only a handful of cases have been reported. Here we present a 15-year-old boy with metastatic RCC with a previous history of advanced stage neuroblastoma and germline mutation in the TP53 tumor suppressor gene. The probability of the RCC and indeed, the neuroblastoma itself being related to a cancer predisposition syndrome rather than a therapy induced second malignancy, is discussed.
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#1Elwira Szychot (ICR: Institute of Cancer Research)H-Index: 4
#2Adam Youssef (GOSH: Great Ormond Street Hospital)H-Index: 2
Last. Ananth Shankar (UCLH: University College Hospital)H-Index: 14
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Abstract BACKGROUND: Diffuse midline gliomas (DMG) are aggressive brain tumours, previously known as diffuse intrinsic pontine gliomas (DIPG), with 10% overall survival (OS) at 18 months. Predicting OS will help refine treatment strategy in this patient group. MRI based texture analysis (MRTA) is novel image analysis technique that provides objective information about spatial arrangement of MRI signal intensity (heterogeneity) and has potential to be imaging biomarker. OBJECTIVES: To investigate...
3 CitationsSource
#1Mechteld C. de Jong (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
#2Mark N. Gaze (GOSH: Great Ormond Street Hospital)H-Index: 28
Last. Tom R. Kurzawinski (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 10
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AIM Differentiated thyroid cancer (DTC) in children and adolescents is rare and data about its presentation and management are not well known. The aim of this study was to provide evidence of the current practice in the United Kingdom before the launch of the Rare National Paediatric Endocrine Tumours Guidelines (to be published in 2020). METHODS Seventy-two children and adolescents with DTC (<18 years) who were treated at our institution between 2003 and 2018 were identified and their presentat...
4 CitationsSource
#1Martijn V VerhagenH-Index: 2
#2Leon Menezes (UCLH: University College Hospital)H-Index: 21
Last. Paul D. Humphries (UCLH: University College Hospital)H-Index: 10
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Rationale: Treatment regimens for pediatric Hodgkin’s lymphoma (HL) depend on accurate staging and treatment response assessment, based on accurate disease distribution and metabolic activity depiction. With the aim of radiation dose reduction, we compared the diagnostic performance of 18F-FDG PET/MR to a 18F-FDG PET/CT reference standard for staging and response assessment. Methods: Twenty-four patients (mean age 15.4 years, range 8-19.5 years) with histologically proven HL were prospectively a...
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#1Matthew D. Aldridge (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 5
#2Connie Peet (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
Last. Mark N. Gaze (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 28
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The common contemporary indications for paediatric molecular radiotherapy (pMRT) are differentiated thyroid cancer and neuroblastoma. It may also have value in neuroendocrine cancers, and it is being investigated in clinical trials for other diseases. pMRT is the prototypical biomarker-driven, precision therapy, with a unique mode of delivery and mechanism of action. It is safe and well tolerated, compared with other treatments. However, its full potential has not yet been achieved, and its wide...
1 CitationsSource
Background To assess anatomical and quantitative diffusion-weighted MR imaging features in a recently classified lethal neoplasm, H3 K27M histone-mutant diffuse midline glioma [World Health Organization (WHO) IV]. Methods Fifteen untreated gliomas in teenagers and adults (median age 19, range, 14-64) with confirmed H3 K27M histone-mutant genotype were analysed at a national referral centre. Morphological characteristics including tumour epicentre(s), T2/FLAIR and Gadolinium enhancement patterns,...
2 CitationsSource
#1Valentina Ferrazzoli (UCLH: University College Hospital)
#2Ananth Shankar (UCLH: University College Hospital)H-Index: 14
Last. Harpreet Hyare (UCLH: University College Hospital)H-Index: 6
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#1Elwira Szychot (UCLH: University College Hospital)H-Index: 4
#2Adam Youssef (GOSH: Great Ormond Street Hospital)H-Index: 2
Last. Kshitij Mankad (GOSH: Great Ormond Street Hospital)H-Index: 21
view all 8 authors...
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#1Ananth Shankar (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 14
#2Jamshed Bomanji (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 12
Last. Harpreet Hyare (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 6
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(1) Background: Standard magnetic resonance imaging (MRI) remains the gold standard for brain tumour imaging in paediatric and teenage and young adult (TYA) patients. Combining positron emission tomography (PET) with MRI offers an opportunity to improve diagnostic accuracy. (2) Method: Our single-centre experience of 18F-fluorocholine (FCho) and 18fluoro-L-phenylalanine (FDOPA) PET–MRI in paediatric/TYA neuro-oncology patients is presented. (3) Results: Hybrid PET–MRI shows promise in the evalua...
1 CitationsSource
#1Jennifer E. GainsH-Index: 9
#2Matthew D. Aldridge (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 5
Last. Mark N. GazeH-Index: 28
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PURPOSE Iodine-131-labelled meta-iodobenzylguanidine (I-mIBG) and lutetium-177-labelled DOTATATE (Lu-DOTATATE) are used for molecular radiotherapy of metastatic neuroblastoma. These are taken up by the noradrenaline transporter (NAT) and the somatostatin receptor subtype 2 (SSTR-2), respectively. Scintigraphy of iodine-123-labelled meta-iodobenzylguanidine (I-mIBG) and gallium-68 DOTATATE (Ga-DOTATATE) PET are used to select patients for therapy. These demonstrate the extent and location of tumo...
5 CitationsSource