The idiopathic intracranial hypertension treatment trial: design considerations and methods.

Published on Jun 1, 2014in Journal of Neuro-ophthalmology3.042
路 DOI :10.1097/WNO.0000000000000114
Mark J. Kupersmith39
Estimated H-index: 39
(ISMMS: Icahn School of Medicine at Mount Sinai)
Sources
Abstract
Background:The objectives of this study were to present the rationale for the main aspects of the study design and describe the trial methodology for the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT).Methods:Eligible candidates with mild visual field loss (automated perimetric mean de
馃摉 Papers frequently viewed together
20142.47JAMA
10 Authors (Mark J. Kupersmith)
10 Authors (Mark J. Kupersmith)
References45
Newest
#5Mark L. Moster (Albert Einstein Medical Center)H-Index: 10
Purpose Obesity and weight gain are known risk factors for idiopathic intracranial hypertension (IIH; or pseudotumor cerebri). The authors examined profiles of body mass index (BMI) and patterns of weight gain associated with IIH. They also examined vision-specific health-related quality of life (HRQOL) in newly diagnosed IIH patients and explored the relative contribution of obesity and weight gain to overall HRQOL in this disorder. Design Matched case-control study. Methods Female patients wit...
Source
#1Brian Wansink (Ad: INSEAD)H-Index: 90
#2Pierre Chandon (Ad: INSEAD)H-Index: 32
Trained interviewers asked fast-food restaurant customers to estimate the calorie content of their meals. Interviewers counted the empty food containers on each participant's tray and calculated th...
Source
#1Jenny H. Ledikwe (PSU: Pennsylvania State University)H-Index: 12
#2Heidi M. BlanckH-Index: 58
Last. Barbara J. RollsH-Index: 111
view all 7 authors...
Abstract Objective This study investigated food choices made by individuals consuming diets differing in energy density and explores relationships between energy density and diet quality. Design Cross-sectional, nationally representative survey. Subjects 7,500 adults (older than 19 years) in the 1994-1996 Continuing Survey of Food Intakes by Individuals. Statistical Analysis Energy density values were calculated from reported food intake. Subjects were classified as consuming a low-energy-densit...
Source
A substantial body of evidence strongly supports the concept that multiple dietary factors affect blood pressure (BP). Well-established dietary modifications that lower BP are reduced salt intake, weight loss, and moderation of alcohol consumption (among those who drink). Over the past decade, increased potassium intake and consumption of dietary patterns based on the 鈥淒ASH diet鈥 have emerged as effective strategies that also lower BP. Of substantial public health relevance are findings related ...
Source
#1Geert MolenberghsH-Index: 84
#2Herbert ThijsH-Index: 23
Last. Raymond J. Carroll (A&M: Texas A&M University)H-Index: 118
view all 7 authors...
SUMMARY Using standard missing data taxonomy, due to Rubin and co-workers, and simple algebraic derivations, it is argued that some simple but commonly used methods to handle incomplete longitudinal clinical trial data, such as complete case analyses and methods based on last observation carried forward, require restrictive assumptions and stand on a weaker theoretical foundation than likelihood-based methods developed under the missing at random (MAR) framework. Given the availability of flexib...
Source
#1Brian Wansink (UIUC: University of Illinois at Urbana鈥揅hampaign)H-Index: 90
鈻 Abstract鈥侾ackage size, plate shape, lighting, socializing, and variety are only a few of the environmental factors that can influence the consumption volume of food far more than most people realize. Although such environmental factors appear unrelated, they generally influence consumption volume by inhibiting consumption monitoring and by suggesting alternative consumption norms. For researchers, this review suggests that redirecting the focus of investigations to the psychological mechanisms...
Source
Chromosomal passenger proteins undergo spectacular changes in localization during cell division. We now have molecular insight into how and why these changes occur.
Source
#1Mark KosinskiH-Index: 54
#2Martha S. BaylissH-Index: 24
Last. Stewart J. TepperH-Index: 61
view all 10 authors...
Background: Migraine and other severe headaches can cause suffering and reduce functioning and productivity. Patients are the best source of information about such impact. Objective: To develop a new short form (HIT-6) for assessing the impact of headaches that has broad content coverage but is brief as well as reliable and valid enough to use in screening and monitoring patients in clinical research and practice. Methods: HIT-6 items were selected from an existing item pool of 54 items and from...
Source
#3Nicolaas P. Pronk (Regions Hospital)H-Index: 48
#7Kerrin Brelje (UMN: University of Minnesota)H-Index: 9
OBJECTIVE: To describe methods, recruitment success, and 1-y results of a study evaluating the effectiveness of phone- and mail-based weight-loss interventions in a managed care setting. DESIGN: Randomized clinical trial with three groups, that is, usual care, mail intervention, and phone intervention. SUBJECTS: In total, 1801 overweight members of a managed-care organization (MCO). MEASUREMENTS: Height, weight, medical status, and weight-loss history were measured at baseline. Participation in ...
Source
#1S. B. Heymsfield (Columbia University)H-Index: 22
#2C A J van MierloH-Index: 1
Last. H I FrierH-Index: 1
view all 5 authors...
OBJECTIVE: Although used by millions of overweight and obese consumers, there has not been a systematic assessment on the safety and effectiveness of a meal replacement strategy for weight management. The aim of this study was to review, by use of a meta- and pooling analysis, the existing literature on the safety and effectiveness of a partial meal replacement (PMR) plan using one or two vitamin/mineral fortified meal replacements as well as regular foods for long-term weight management. DESIGN...
Source
Cited By54
Newest
#1Raed BehbehaniH-Index: 16
#2Abdullah E AliH-Index: 2
view all 3 authors...
Source
#1Brianna N Brun (Nationwide Children's Hospital)
#2Shawn C. Aylward (Nationwide Children's Hospital)H-Index: 7
Abstract null null Primary intracranial hypertension (PIH) is characterized by clinical signs of increased intracranial pressure, papilledema, elevated opening pressure, and absence of mass lesion, hydrocephalus, or meningeal enhancement on neuroimaging. Visual changes are a common presenting feature and if untreated there is risk of irreversible vision loss. There have been recent proposed changes to the criteria for PIH along with studies looking at the differences in imaging characteristics b...
Source
BACKGROUND Idiopathic Intracranial Hypertension (IIH) diagnosis requires lumbar puncture to measure cerebrospinal fluid (CSF) pressure. The Pre-Lumbar puncture Intracranial Hypertension Scale (PLIHS) is aimed to detect cases that will show raised or normal CSF opening pressure. METHODS Retrospective analysis of records of patients who underwent lumbar puncture for suspect IIH. The target was CSF opening pressure聽鈮ヂ250 mmH2O, whereas a set of known neurological, neuro-ophthalmological and neuro-r...
Source
#1Leyla Telhan (Istanbul Medipol University)H-Index: 2
#2Murat Begenik (Istanbul Medipol University)
Last. 脰nder Yava艧can (Istanbul Medipol University)H-Index: 2
view all 4 authors...
Source
#1Andreas Yiangou (HealthPartners)H-Index: 11
#2James L Mitchell (HealthPartners)H-Index: 12
Last. Alexandra J Sinclair (HealthPartners)H-Index: 30
view all 10 authors...
OBJECTIVE To determine the effectiveness of erenumab in treating headaches in idiopathic intracranial hypertension (IIH) in whom papilledema had resolved. BACKGROUND Disability in IIH is predominantly driven by debilitating headaches with no evidence for the use of preventative therapies. Headache therapy in IIH is an urgent unmet need. METHODS A prospective, open-label study in the United Kingdom was conducted. Adult females with confirmed diagnosis of IIH now in ocular remission (papilledema r...
Source
#1Deborah I. FriedmanH-Index: 38
Source
#1Allison R. Loiselle (UMCG: University Medical Center Groningen)H-Index: 3
#2Emile de Kleine (UMCG: University Medical Center Groningen)H-Index: 13
Last. Nomdo M. Jansonius (UMCG: University Medical Center Groningen)H-Index: 37
view all 4 authors...
The alternative mechanical theory of glaucoma, in which an increased pressure difference across the lamina cribrosa (difference between intraocular and intracranial pressure; IOP and ICP), rather than solely an elevated IOP, leads to structural and functional vision loss, is still controversial. If the theory is true, a drug that simultaneously lowers both the IOP and ICP may be ineffective. The aim of this study was to determine how acetazolamide (AAZ; a drug prescribed in glaucoma that aims to...
Source
#1Yazhi Zhang (HUST: Huazhong University of Science and Technology)
#2Yining Qiu (HUST: Huazhong University of Science and Technology)H-Index: 2
Last. Xiaoyan Wu (HUST: Huazhong University of Science and Technology)H-Index: 6
view all 7 authors...
A 7-month-old baby girl with acute lymphoblastic leukemia (ALL) presented with bulging anterior fontanelle after completing the first and second courses of high-dose methotrexate (HD-MTX) chemotherapy. Between courses, the infant recovered and was discharged. Prior to the third and fourth HD-MTX courses, the baby girl was administered infusions of dexamethasone, which prevented recurrence of neurological side effects observed after the first and second courses of HD-MTX. To our knowledge, this i...
Source
#1Weijie V. LinH-Index: 8
#2Shauna BerryH-Index: 4
Last. Andrew G. LeeH-Index: 64
view all 5 authors...
BACKGROUND: An association between idiopathic intracranial hypertension (IIH) and anemia has been speculated from previous case reports and case series. Retrospective studies to date have not used matched case controls to compare standardized complete blood count (CBC) values for the presence of anemia. METHODS: At our tertiary care facility, 50 patients with IIH were matched with 50 case-control patients to compare CBC values from laboratory affiliates with standardized ranges. RESULTS: No sign...
Source
#1Mahmoud H Mohammaden (UIC: University of Illinois at Chicago)H-Index: 7
#2Muhammad Rizwan Husain (UIC: University of Illinois at Chicago)H-Index: 1
Last. Ali Alaraj (UIC: University of Illinois at Chicago)H-Index: 24
view all 7 authors...
BACKGROUND: The resistivity index (RI) in cerebral venous sinus stenosis (VSS) has not been studied in patients with idiopathic intracranial hypertension (IIH). OBJECTIVE: To evaluate the role of RI measured by quantitative magnetic resonance venogram (QMRV) as a noninvasive tool in the diagnosis of venous hypertension associated with VSS in IIH. METHODS: Retrospective evaluation of 13 consecutive IIH patients who underwent venous sinus stenting at our institution between 2013 and 2018.Patients'...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.