Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression

Volume: 35, Issue: 50, Pages: 6366 - 6377
Published: Apr 4, 2016
Abstract
Tumour tissue is infiltrated by myeloid cells that are reprogrammed into alternatively activated/regenerative (M2) macrophages. The contribution of major signalling pathways and their modulators/targets involved in the macrophage reprogramming is poorly known. Glioblastoma (malignant brain tumour) attracts and reprograms brain-resident microglia and peripheral macrophages into cells that increase invasion, angiogenesis and suppress antitumour...
Paper Details
Title
Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression
Published Date
Apr 4, 2016
Journal
Volume
35
Issue
50
Pages
6366 - 6377
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