Metabolites of Antibody–Maytansinoid Conjugates: Characteristics and in Vitro Potencies
Abstract
Several antibody-maytansinoid conjugates (AMCs) are in clinical trials for the treatment of various cancers. Each of these conjugates can be metabolized by tumor cells to give cytotoxic maytansinoid metabolites that can kill targeted cells. In preclinical studies in mice, the cytotoxic metabolites initially formed in vivo are further processed in the mouse liver to give several oxidized metabolic species. In this work, the primary AMC...
Paper Details
Title
Metabolites of Antibody–Maytansinoid Conjugates: Characteristics and in Vitro Potencies
Published Date
Apr 8, 2015
Journal
Volume
12
Issue
6
Pages
1762 - 1773
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