Review paper

An Update on the Use of Animal Models in Diabetic Nephropathy Research

Volume: 16, Issue: 2
Published: Jan 27, 2016
Abstract
In the current review, we discuss limitations and recent advances in animal models of diabetic nephropathy (DN). As in human disease, genetic factors may determine disease severity with the murine FVB and DBA/2J strains being more susceptible to DN than C57BL/6J mice. On the black and tan, brachyuric (BTBR) background, leptin deficient (ob/ob) mice develop many of the pathological features of human DN. Hypertension synergises with hyperglycemia...
Paper Details
Title
An Update on the Use of Animal Models in Diabetic Nephropathy Research
Published Date
Jan 27, 2016
Volume
16
Issue
2
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