Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4

Volume: 324, Pages: 399 - 406
Published: Jun 1, 2016
Abstract
An orphan member of the solute carrier (SLC) family SLC10, SLC10A4 has been found to be enriched in midbrain and brainstem neurons and has been found to co-localize with and to affect dopamine (DA) homeostasis. We generated an SLC10A4 knockout mouse (Slc10a4(Δ/Δ)) using Cre-targeted recombination, and characterized behavioral measures of motor and cognitive function as well as DA and acetylcholine (ACh) levels in midbrain and brainstem. In...
Paper Details
Title
Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4
Published Date
Jun 1, 2016
Volume
324
Pages
399 - 406
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