Original paper
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
Abstract
Mechanosensitive ion channels are force-transducing enzymes that couple mechanical stimuli to ion flux. Understanding the gating mechanism of mechanosensitive channels is challenging because the stimulus seen by the channel reflects forces shared between the membrane, cytoskeleton and extracellular matrix. Here we examine whether the mechanosensitive channel PIEZO1 is activated by force-transmission through the bilayer. To achieve this, we...
Paper Details
Title
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
Published Date
Jan 20, 2016
Journal
Volume
7
Issue
1
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Notes
History