Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system
Abstract
Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin II, which regulates blood pressure, fluid and electrolyte balance and is a biomarker for cardiovascular, metabolic and renal function. The renin-angiotensin...
Paper Details
Title
Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system
Published Date
Mar 11, 2016
Journal
Volume
17
Issue
1
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