Nilima Biswas
University of California, San Diego
GeneInternal medicinePhenotypeEndocrinologySingle-nucleotide polymorphismMolecular biologyReceptorAlleleChemistryCatecholaminePeptidePopulationSecretionGeneticsBiochemistryGenetic variationMedicineChromogranin ALocus (genetics)BiologyNeuropeptide Y receptor
38Publications
16H-index
817Citations
Publications 34
Newest
#1Hong Xin (UCSD: University of California, San Diego)H-Index: 2
#2Nilima Biswas (UCSD: University of California, San Diego)H-Index: 16
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 7 authors...
Neovascularization is a key feature of ischemic retinal diseases and the wet form of age-related macular degeneration (AMD), all leading causes of severe vision loss. Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of these disorders. Millions of patients have been treated with these drugs worldwide. However, in real-life clinical settings, many patients do not experience the same degree of benefit observed in clinical trials, in part because they receive fewe...
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#1Saiful A. MirH-Index: 6
#2Nilima BiswasH-Index: 16
Last. Sucheta M. VaingankarH-Index: 20
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BACKGROUND: Chromogranin A (CHGA) is an index granin protein critical for biogenesis and exocytotic release of catecholamine storage granules. It is elevated in plasma of patients with sympathetic over-activity and kidney dysfunction. Several CHGA polymorphisms are associated with hypertensive kidney disease. Previously, we unraveled the molecular mechanism by which CHGA expression is regulated in African Americans carrying a genetic variation associated with hypertensive chronic kidney disease ...
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#1Jose Pablo Miramontes-Gonzalez (UCSD: University of California, San Diego)H-Index: 7
#2C. Makena Hightower (UCSD: University of California, San Diego)H-Index: 8
Last. Daniel T. O'Connor (UCSD: University of California, San Diego)H-Index: 117
view all 16 authors...
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#1Jose Pablo Miramontes-Gonzalez (UCSD: University of California, San Diego)H-Index: 7
#2C. Makena Hightower (UCSD: University of California, San Diego)H-Index: 8
Last. Daniel T. O'Connor (UCSD: University of California, San Diego)H-Index: 117
view all 16 authors...
The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the development of nephropathy. In the kidney, the enzyme DOPA Decarboxylase (DDC) originating from the circulation. We used a twin/family study design, followed by polymorphism association analysis at DDC locus to elucidate heritable influences on renal DA production. Dense single nucleotide polymorphism (SNP) genotyping across the DDC locus on chr...
3 CitationsSource
#2Saiful A. MirH-Index: 6
Last. Daniel T. O'ConnorH-Index: 117
view all 5 authors...
Introduction: Chromogranin A (CHGA) is released into circulation with catecholamine from secretory granules of chromaffin cells and post-ganglionic sympathetic neurons. Several CHGA gene polymorphi...
#1Beben Benyamin (UQ: University of Queensland)H-Index: 29
#2Adam X. MaihoferH-Index: 20
Last. Daniel T. O'ConnorH-Index: 117
view all 18 authors...
Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, with effects on control of blood pressure. We conducted a genome-wide association study for plasma catestatin, the catecholamine release inhibitory peptide derived from chromogranin A (CHGA), and other CHGA- or chromogranin B (CHGB)-related peptides, in 545 US and 1252 Australian subjects. This identified loci on chromosomes 4q35 and 5q34 affecting catestatin concentration (P = 3.40 × 10-30 for rs4253311 and 1.8...
10 CitationsSource
#1Nilima Biswas (UCSD: University of California, San Diego)H-Index: 16
#2Adam X. MaihoferH-Index: 20
Last. Daniel T. O'Connor (UCSD: University of California, San Diego)H-Index: 117
view all 14 authors...
Background Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin II, which regulates blood pressure, fluid and electrolyte balance and is a biomarker for cardiovascular, metabolic and renal function. The renin-angiotensin system is implicated in extinction learning ...
8 CitationsSource
#1Christine U. VuH-Index: 3
#2Jawed A. Siddiqui (UCSD: University of California, San Diego)H-Index: 2
Last. Sushil K. Mahata (UCSD: University of California, San Diego)H-Index: 64
view all 10 authors...
Cigarette smoking causes insulin resistance. However, nicotine induces anti-inflammation and improves glucose tolerance in insulin-resistant animal models. Here, we determined the effects of nicotine on glucose metabolism in insulin-sensitive C57BL/J6 mice. Acute nicotine administration (30 min) caused fasting hyperglycemia and lowered insulin sensitivity acutely, which depended on the activation of nicotinic-acetylcholine receptors (nAChRs) and correlated with increased catecholamine secretion,...
23 CitationsSource
#1Satish A. Eraly (UCSD: University of California, San Diego)H-Index: 26
#2Caroline M. Nievergelt (UCSD: University of California, San Diego)H-Index: 62
Last. Dewleen G. Baker (UCSD: University of California, San Diego)H-Index: 59
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RESULTS We determined the effects of baseline plasma CRP concentration on postdeployment CAPS using zero-inflated negative binomial regression (ZINBR), a procedure designed for distributions, such as CAPS in this study, that have an excess of zeroes in addition to being positively skewed. Adjusting for the baseline CAPS score, trauma exposure, and other relevant covariates, we found baseline plasma CRP concentration to be a highly significant overall predictor of postdeployment CAPS scores (P = ...
179 CitationsSource
#1Kuixing Zhang (UCSD: University of California, San Diego)H-Index: 19
#2Nilima Biswas (UCSD: University of California, San Diego)H-Index: 16
Last. Daniel T. O'Connor (UCSD: University of California, San Diego)H-Index: 117
view all 12 authors...
Chromogranin B (CHGB) is the major matrix protein in human catecholamine storage vesicles. CHGB genetic variation alters catecholamine secretion and blood pressure. Here, effective Chgb protein under-expression was achieved by siRNA in PC12 cells, resulting in ~ 48% fewer secretory granules on electron microscopy, diminished capacity for catecholamine uptake (by ~ 79%), and a ~ 73% decline in stores available for nicotinic cholinergic-stimulated secretion. In vivo, loss of Chgb in knockout mice ...
13 CitationsSource