Is CEM43 still a relevant thermal dose parameter for hyperthermia treatment monitoring?

CEM43 has its roots in the direct cytotoxic effect of heat, whereby the amount of cell death depends on the temperature and exposure time. CEM43 is a normalising method to convert the various time-temperature exposures applied into an equivalent exposure time expressed as minutes at the reference temperature of 43 °C. The CEM43 concept also holds a number of weaknesses, however. When used to predict treatment efficacy of combined radiotherapy...