Original paper
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer
Abstract
HER2-positive advanced gastric cancer patients frequently develop resistance to trastuzumab through mechanisms still poorly understood. In breast cancer, other members of the HER-family are known to be involved in trastuzumab-resistance, as is overexpression of the scaffold protein IQGAP1. In the present work, we investigated acquired resistance to trastuzumab in gastric cancer experimental models. Trastuzumab-resistant (HR) subclones derived...
Paper Details
Title
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer
Published Date
Feb 22, 2016
Journal
Volume
7
Issue
14
Pages
18424 - 18439
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Notes
History