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#1Teru Hideshima (Harvard University)H-Index: 133
#2Ralph Mazitschek (Harvard University)H-Index: 53
Last. Kenneth C. Anderson (Harvard University)H-Index: 5
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#1Nivaldo Faria Vieira (USP: University of São Paulo)
#2Luciano Neder Serafini (USP: University of São Paulo)H-Index: 14
Last. Ajith Kumar Sankarankutty (USP: University of São Paulo)H-Index: 13
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Diagnosis and treatment of pancreatic ductal adenocarcinoma (PA) remains a challenge in clinical practice. The aim of this study was to assess the role of microRNAs (miRNAs-21, -23a, -100, -107, -181c, -210) in plasma and tissue as possible biomarkers in the diagnosis of PA. Samples of plasma (PAp-n = 13), pancreatic tumors (PAt-n = 18), peritumoral regions (PPT-n = 9) were collected from patients during the surgical procedure. The control group consisted of samples from patients submitted to pa...
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#1Ming Chen (MSU: Michigan State University)
#2Zdravka Medarova (Harvard University)H-Index: 29
Last. Anna Moore (MSU: Michigan State University)H-Index: 5
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Glioblastoma is the most common and aggressive primary human brain cancer. MicroRNAs (miRNAs) are a set of small endogenous non-coding RNA molecules which play critical roles in different biological processes including cancer. The realization of miRNA regulatory functions in GBM has demonstrated that these molecules play a critical role in its initiation, progression and response to therapy. In this review we discuss the studies related to miRNA discovery and function in glioblastoma. We first s...
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#1Ayumu Asai (Osaka University)H-Index: 10
#2Masamitsu Konno (Ridai: Tokyo University of Science)H-Index: 22
Last. Hideshi Ishii (Osaka University)H-Index: 60
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Although early detection and diagnosis are indispensable for improving the prognosis of patients with pancreatic cancer, both have yet to be achieved. Except for pancreatic cancer, other cancers have already been screened through scent tests using animals or microorganisms, including Caenorhabditis elegans. While such a method may greatly improve the prognosis of pancreatic cancer, no studies have investigated the same, mainly given the difficulty of collecting suitable samples from patients wit...
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#1Miguel Vizoso (NKI-AVL: Netherlands Cancer Institute)H-Index: 13
#2Jacco van Rheenen (NKI-AVL: Netherlands Cancer Institute)H-Index: 38
DNA methylation is an epigenetic process that controls DNA accessibility and serves as a transcriptomic switch when deposited at regulatory regions. The adequate functioning of this process is indispensable for tissue homeostasis and cell fate determination. Conversely, altered DNA methylation patterns result in abnormal gene transcription profiles that contribute to tumor initiation and progression. However, whether the consequence of DNA methylation on gene expression and cell fate is uniform ...
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#1Gyselle Ribeiro de Carvalho Oliveira (UFPA: Federal University of Pará)
#2Carla de Castro Sant’ Anna (LUC: Loyola University Chicago)
Last. Rommel Rodriguez Burbano (LUC: Loyola University Chicago)H-Index: 11
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The loss of teeth and lack of oral hygiene have been associated with the risk of developing gastric cancer (GC) in several populations evidenced in epidemiological studies. In this study, we quantitatively compared the proportion of oral pathogens in individuals with gastric cancer and individuals without cancer in a referral hospital in the city of Belem, Brazil. This study evaluated 192 patients with GC and 192 patients without cancer. Periodontal clinical examination was performed, and all in...
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#1Giovanna Casili (UNIME: University of Messina)H-Index: 10
#2Sarah Adriana Scuderi (UNIME: University of Messina)H-Index: 3
Last. Irene Paterniti (UNIME: University of Messina)H-Index: 32
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Intestinal ischemia-reperfusion (II/R) develops when the blood flow to the intestines decreases, followed by the reestablishment of the blood supply to the ischemic tissue, resulting in intestinal mucosal barrier dysfunction, with consequent severe local and systemic inflammation. Acute lung injury (ALI) represents the most serious complication after II/R. KYP-2047 is a selective inhibitor of prolyl oligopeptidase (POP), a serine protease involved in the release of pro-angiogenic and inflammator...
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#1Alisa A. Petkevich (Peoples' Friendship University of Russia)
#2Aleksandr Andreevich Abramov (Peoples' Friendship University of Russia)
Last. O. I. Tarasova (Peoples' Friendship University of Russia)
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Patients with HCV-related cirrhosis are at risk for liver cancer development. For these patients miRNAs may serve as preclinical markers, which expression levels are deregulated in cancer and which are stable to the damaging factors partly through complex formation with proteins or packaging into exosomes. In this research we have tried to identify what miRNA fraction in plasma - exosomal or not packed into exosomes (non-exosomal) - is stronger associated with primary liver cancer. The second qu...
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#2Yee Pei Song (University of Manchester)H-Index: 4
Last. Ananya Choudhury (University of Manchester)H-Index: 28
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One third of patients with bladder cancer present with muscle invasive bladder cancer (MIBC) which has a poor prognosis. International guidelines for the management of MIBC recommend radical cystectomy or bladder-preserving treatment based on radical radiotherapy with a form of radiosensitisation. In the UK, both conventional fractionation with 64 Gy in 32 fractions and hypofractionation with 55 Gy in 20 fractions are standard of care options with the choice varying between centres. A meta-analy...
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