TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle

Volume: 35, Issue: 32, Pages: 4212 - 4224
Published: Dec 21, 2015
Abstract
Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children that shares many features of developing skeletal muscle. TBX2, a T-box family member, is highly upregulated in tumor cells of both major RMS subtypes where it functions as an oncogene. TBX2 is a repressor that is often overexpressed in cancer cells and functions in bypassing cell growth control, including the repression of the cell cycle regulators p14 and p21. We have...
Paper Details
Title
TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle
Published Date
Dec 21, 2015
Journal
Volume
35
Issue
32
Pages
4212 - 4224
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