Reproducibility of Variant Calls in Replicate Next Generation Sequencing Experiments
Abstract
Nucleotide alterations detected by next generation sequencing are not always true biological changes but could represent sequencing errors. Even highly accurate methods can yield substantial error rates when applied to millions of nucleotides. In this study, we examined the reproducibility of nucleotide variant calls in replicate sequencing experiments of the same genomic DNA. We performed targeted sequencing of all known human protein kinase...
Paper Details
Title
Reproducibility of Variant Calls in Replicate Next Generation Sequencing Experiments
Published Date
Jul 2, 2015
Journal
Volume
10
Issue
7
Pages
e0119230 - e0119230
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