Original paper
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Abstract
Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation. However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically elastic. Here, we report a materials approach to tune the rate of stress relaxation of hydrogels for 3D culture, independently of the hydrogel’s initial elastic modulus, degradation, and cell-adhesion-ligand density. We find that cell spreading, proliferation, and...
Paper Details
Title
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Published Date
Nov 30, 2015
Journal
Volume
15
Issue
3
Pages
326 - 334
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Notes
History