Immune-related adverse events with immune checkpoint blockade: a comprehensive review
Abstract
Cancer immunotherapy is coming of age; it has prompted a paradigm shift in oncology, in which therapeutic agents are used to target immune cells rather than cancer cells. The first generation of new immunotherapies corresponds to antagonistic antibodies that block specific immune checkpoint molecules cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell death protein (PD-1) and its ligand PD-L1. Targeting these checkpoints in...
Paper Details
Title
Immune-related adverse events with immune checkpoint blockade: a comprehensive review
Published Date
Feb 1, 2016
Journal
Volume
54
Pages
139 - 148
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Notes
History