Abstract null null Purpose null Sarcoid-like granulomatosis (SLG) reaction caused by immunotherapy remains poorly understood. This study aims to investigate the outcome of patients with cancer and SLG associated with immunotherapy. null null null Patients and methods null Between April 2016 and June 2020, 434 patients with immunological adverse events were screened from the ImmunoTOX assessment board of Gustave Roussy, an academic cancer centre in France. Among them, 28 patients had SLG associat...
#2Henning Reis(University of Duisburg-Essen)H-Index: 25
Last. Joachim Klode(University of Duisburg-Essen)H-Index: 29
view all 7 authors...
Abstract null null Introduction null The Covid-19 pandemic has changed the lives of people around the world. Fortunately, sufficient vaccines are now available. Local reactions with ipsilateral lymphadenopathy are among the most common side effects. We investigated the impact of lymphadenopathy after Covid-19 vaccination on the value of ultrasound in tumor patients. null null null Patients and methods null Patients with melanoma or merkel cell carcinoma were included who underwent lymph node exc...
Abstract null null Human microbiota plays a key role in preserving homeostasis; therefore, alteration in its composition is associated with susceptibility to various diseases. Recent findings suggest that gut microbiota may influence response to cancer treatment, especially immune checkpoint blockers (ICBs). The development of ICBs has changed outcomes of patients with cancer and has allowed sustained recovery. Unfortunately, some patients do not respond to ICBs, and microbiota may be a promisin...
Abstract null null Background null There is no standard chemotherapy for esophageal squamous cell carcinoma (ESCC) refractory to first-line fluoropyrimidine- and platinum-based chemotherapy. We therefore performed a randomized, selection-design phase II trial to compare docetaxel (DTX) and paclitaxel (PTX) in this setting. null null null Patients and methods null Eligible patients were randomly assigned to receive either DTX (70 mg/m2 on day 1 of each 21-day cycle) or PTX (100 mg/m2 on days 1, 8...
Last. Jin Won Kim(Seoul National University Bundang Hospital)H-Index: 21
view all 10 authors...
Abstract null null Background null In locally advanced or metastatic biliary tract cancer (BTC), second-line chemotherapy is challenging after progression from first-line gemcitabine/cisplatin. This study evaluated whether irinotecan/5-fluorouracil (5-FU; mFOLFIRI) was superior to oxaliplatin/5-FU (mFOLFOX) as a second-line treatment in BTC. null null null Patients and methods null Patients diagnosed with BTC with disease progression after prior gemcitabine/cisplatin were randomised (1:1) to eit...
Abstract null null Background null Patients with advanced pancreatic cancer (PC) have a high risk of dying in the short or medium-term. This overview aimed to assess the evidence regarding systemic oncological treatments (SOT) versus supportive care for advanced PC. null null null Methods null We searched for systematic reviews (SRs) in MEDLINE, Embase, The Cochrane Library, Epistemonikos, and PROSPERO. Two authors assessed eligibility independently. Data extraction and methodological quality as...
Last. Harry Bartelink(NKI-AVL: Netherlands Cancer Institute)H-Index: 91
view all 11 authors...
Abstract null null Purpose null To analyse the prognostic impact of isolated local recurrence (ILR) on long-term outcome for early-breast cancer patients treated with breast-conserving therapy. null null null Material and methods null The data of the EORTC 22881–10882 ‘boost-no boost’ and 22922–10925 ‘IM-MS’ trials were used to analyse the prevalence and outcome following ILR. A multistate model described the impact of intermediate events on long-term outcomes, taking into account various progno...
Last. Gianluca Tomasello(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 24
view all 24 authors...
Abstract null null Background null We performed a comprehensive genomic profiling of tumour samples from metastatic colorectal cancer (mCRC) patients enrolled in the TRIBE2 study to assess the concordance among different techniques to evaluate mismatch repair (MMR) and microsatellite instability (MSI) status, to characterize tumours according to the tumour mutational burden (TMB) and explore the clinical relevance of different TMB cutpoints, and to investigate the prevalence of alterations actio...
Abstract null null Objective null To analyse the clinical patterns of sarcoidosis triggered by immune checkpoint inhibitors (ICIs) in patients with cancer. null null null Patients and methods null The ImmunoCancer International Registry is a big data–sharing multidisciplinary network from 18 countries dedicated to evaluating the clinical research of immune-related adverse events related to cancer immunotherapies. null null null Results null We identified 32 patients with biopsy-proven sarcoidosi...