Profile of rheumatology patients willing to report adverse drug reactions: bias from selective reporting.

Published on Feb 2, 2016in Patient Preference and Adherence2.711
· DOI :10.2147/PPA.S96449
Dragana Protic7
Estimated H-index: 7
Nada Vujasinovic-Stupar5
Estimated H-index: 5
(University of Belgrade)
+ 6 AuthorsZoran Todorovic12
Estimated H-index: 12
(University of Belgrade)
Background: Adverse drug reactions (ADRs) have a significant impact on human health and health care costs. The aims of our study were to determine the profile of rheumatology patients willing to report ADRs and to identify bias in such a reporting system. Methods: Semi-intensive ADRs reporting system was used in our study. Patients willing to participate (N=261) completed the questionnaire designed for the purpose of the study at the hospital admission. They were subsequently classified into two groups according to their ability to identify whether they had experienced ADRs during the previous month. Group 1 included 214 out of 261 patients who were able to identify ADRs, and group 2 consisted of 43 out of 261 patients who were not able to identify ADRs in their recent medical history. Results: Group 1 patients were more significantly aware of their diagnosis than the patients from group 2. Marginal significance was found between rheumatology patients with and without neuro logical comorbidities regarding their awareness of ADRs. The majority of patients reported ADRs of cytotoxic drugs. The most reported ADRs were moderate gastrointestinal discomforts. Conclusion: We may draw a profile of rheumatological patients willing to report ADRs: 1) The majority of them suffer from systemic inflammatory diseases and are slightly more prone to neurological comorbidities. 2) They are predominantly aware of their diagnosis but less able to identify the drugs that may cause their ADRs. 3) They tend to report mainly moderate gastrointestinal ADRs; that is, other cohorts of patients and other types of ADRs remain mainly undetected in such a reporting, which could represent a bias. Counseling and education of patients as well as developing a network for online communication might improve patients’
#1Snezana MugosaH-Index: 1
#2Zoran BukumiricH-Index: 12
Last. Zoran TodorovicH-Index: 12
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Background/Aim: Adverse drug reactions (ADRs) appear more frequently than actually reported and registered. The main goal of our work was to analyze risk factors, incidence and characteristics of ADRs in hospitalized cardiac patients. Methods. This prospective study included 200 patients, hospitalized at Cardiology Center of the Clinical Centre of Montenegro. ADRs were collected using specially designed questionnaire, based on the list of symptoms and signs that could point out to potential ADRs...
#1Florence van Hunsel (UG: University of Groningen)H-Index: 15
#2Linda Härmark (UG: University of Groningen)H-Index: 15
Last. Kees van Grootheest (UG: University of Groningen)H-Index: 22
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Background: Patients are important stakeholders in pharmacovigilance; however, little formal evaluation has been undertaken of existing patient reporting schemes within and outside Europe. If patient reporting is to be recognized as beneficial for pharmacovigilance and further optimized, methodology and best practice must be internationally shared and promoted.
#1Felipe Azevedo Moretti (Cochrane Collaboration)H-Index: 4
#2Vanessa Elias de Oliveira (UFABC: Universidade Federal do ABC)H-Index: 8
Last. Edina Mariko Koga da Silva (UNIFESP: Federal University of São Paulo)H-Index: 24
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OBJETIVO: Avancar no entendimento sobre o perfil do usuario e as tendencias de busca por informacoes de saude na internet. METODOS: As analises foram feitas a partir de 1.828 individuos que responderam a um questionario eletronico disponibilizado em um portal de saude de grande acesso. Paralelamente, por meio do metodo de "survey de elites", 20 especialistas foram entrevistados para avaliar estrategias de controle de qualidade das informacoes de saude veiculadas na rede. RESULTADOS: Verificou-se...
#1Marinela Z. Knezevic (University of Kragujevac)H-Index: 3
#2Ivana C. Bivolarevic (University of Kragujevac)H-Index: 2
Last. Slobodan M. Jankovic (University of Kragujevac)H-Index: 23
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#1Lotta Gäwert (Charité)H-Index: 1
#2Franka Hierse (Charité)H-Index: 1
Last. Anja Strangfeld (Charité)H-Index: 1
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Objective. To analyse the validity of patient reports on adverse drug reactions (ADRs) compared with the reports given by the treating physician. Methods. Patients with RA enrolled in the German biologics register rheumatoid arthritis observation of biologic therapy (RABBIT) between May 2001 and September 2006 were included in the study. We investigated concordance of reporting and level of agreement between physician- and patient-reported ADRs, taking the physician as gold standard. Results. Da...
#1Phil Edwards (Lond: University of London)H-Index: 50
A good questionnaire design for a clinical trial will minimise bias and maximise precision in the estimates of treatment effect within budget. Attempts to collect more data than will be analysed may risk reducing recruitment (reducing power) and increasing losses to follow-up (possibly introducing bias). The mode of administration can also impact on the cost, quality and completeness of data collected. There is good evidence for design features that improve data completeness but further research...
#1Min ZhangH-Index: 21
#2C. D'Arcy J. HolmanH-Index: 50
Last. Max BulsaraH-Index: 72
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Objectives To identify factors that predict repeat admission to hospital for adverse drug reactions (ADRs) in older adults. Design Population based retrospective cohort study. Setting All public and private hospitals in Western Australia. Participants 28 548 patients aged ≥60 years with an admission for an ADR during 1980-2000 followed for three years using the Western Australian data linkage system. Results 5056 (17.7%) patients had a repeat admission for an ADR. Repeat ADRs were associated wit...
#1Alison Blenkinsopp (Keele University)H-Index: 33
#2P. Wilkie (Academy of Medical Royal Colleges)H-Index: 1
Last. Philip Alexander Routledge (Cardiff University)H-Index: 36
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Aims To synthesize data from published studies and international experience to identify evidence of potential benefits and drawbacks of direct patient reporting of suspected adverse drug reactions (ADRs) by patients.
#1Nidhi Sofat (Imperial College London)H-Index: 18
#2O. MalikH-Index: 1
Last. C S HiggensH-Index: 2
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Patients with multi-system rheumatic conditions may have disease affecting the central and peripheral nervous systems. Early assessment is often helpful in averting the development of serious complications, which in some conditions can be prevented by the prompt institution of treatment. We review the spectrum of neurological disease in patients with a rheumatological diagnosis. The wide variety of associated neurological complications is discussed in the context of specific rheumatic conditions...
#1Kendra Schwartz (WSU: Wayne State University)H-Index: 49
#2Thomas RoeH-Index: 1
Last. Anne Victoria NealeH-Index: 25
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We explored a diverse sample of family medicine patients’ use of the internet for health information. Primary objectives were to determine the extent of access to the Internet, and among those with access, the types of health information sought; how they search for that information; and how they assess the accuracy of the information. We also surveyed the physicians’ perceptions of their patients’ use of the Internet for health information. Of 1289 patients participating, 65% reported access to ...
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