Zoran Todorovic
University of Belgrade
PsychiatryInternal medicineEndocrinologyCardiologyIntensive care medicineChemistryStimulationAminophyllineClopidogrelCoconut oilKidneyReperfusion injuryCreatinineFentanylPopulationDrug reactionContractilityAnesthesiaNitric oxideIschemiaMedicineBlood pressureBiologyGastroenterologyPharmacology
Publications 103
Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by an exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ failure. Meldonium is an anti-ischemic and anti-inflammatory agent which negatively interferes with lipid metabolism by shifting energy production from fatty acid oxidation to glycolysis, as a less oxygen-demanding pathway. Thus, we investigated the effects of a four-week meldoni...
#1Marija Zdravkovic (University of Belgrade)H-Index: 11
#2Viseslav PopadicH-Index: 1
Last. Davor MrdaH-Index: 2
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INTRODUCTION: Risk stratification is an important aspect of COVID-19 management, especially in patients admitted to ICU as it can provide more useful consumption of health resources, as well as prioritize critical care services in situations of overwhelming number of patients. MATERIALS AND METHODS: A multivariable predictive model for mortality was developed using data solely from a derivation cohort of 160 COVID-19 patients with moderate to severe ARDS admitted to ICU. The regression coefficie...
#6Milan Dragićević (University of Belgrade)H-Index: 8
#10Ana Todorovic (University of Belgrade)H-Index: 3
Thioacetamide (TAA) is widely used to study liver toxicity accompanied by oxidative stress, inflammation, cell necrosis, fibrosis, cholestasis, and hepatocellular carcinoma. As an efficient free radical’s scavenger, C60 fullerene is considered a potential liver-protective agent in chemically-induced liver injury. In the present work, we examined the hepatoprotective effects of two C60 doses dissolved in virgin olive oil against TAA-induced hepatotoxicity in rats. We showed that TAA-induced incre...
Introduction. Mortality among critically ill COVID-19 patients remains relatively high despite different potential therapeutic modalities being introduced recently. The treatment of critically ill patients is a challenging task, without identified credible predictors of mortality. Methods. We performed an analysis of 160 consecutive patients with confirmed COVID-19 infection admitted to the Respiratory Intensive Care Unit between June 23, 2020, and October 2, 2020, in University Hospital Center ...
Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases' incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receivi...
Lipids play an essential role in both tissue protection and damage. Tissue ischemia creates anaerobic conditions in which enzyme inactivation occurs, and reperfusion can initiate oxidative stress that leads to harmful changes in membrane lipids, the formation of aldehydes, and chain damage until cell death. The critical event in such a series of harmful events in the cell is the unwanted accumulation of fatty acids that leads to lipotoxicity. Lipid analysis provides additional insight into the p...
#1Snezana Mugosa (University of Montenegro)H-Index: 1
#2Zoran Todorovic (University of Belgrade)H-Index: 12
Last. Natasa Djordjevic (University of Kragujevac)H-Index: 14
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Clopidogrel is an antiplatelet drug that displays significant interindividual variability in treatment response. Its bioavailability depends on the function of P-glycoprotein (P-gp), which is coded by a highly polymorphic ABCB1 gene. Thus, the aim of this study was to investigate the effect of ABCB1 genetic polymorphism on clopidogrel efficacy and safety and to determine the frequency distribution of its most common single nucleotide polymorphisms (SNPs) in 106 Montenegrin cardiology patients. C...
#1Siniša Đurašević (University of Belgrade)H-Index: 4
#2Maja Stojković (University of Belgrade)H-Index: 2
Last. Zoran Todorovic (University of Belgrade)H-Index: 12
view all 11 authors...
Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by a...
#1Lucia Martinelli (Science Museum, London)H-Index: 15
#2Vanja Kopilaš (University of Zagreb)H-Index: 2
Last. Srećko Gajović (University of Zagreb)H-Index: 22
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Wearing face masks is recommended as part of personal protective equipment (PPE) and as a public health measure to prevent the spread of COVID-19 pandemic. Their use, however, is deeply connected to social and cultural practices, and has acquired a variety of personal and social meanings. This article aims to identify the diversity of socio-cultural, ethical, and political meanings attributed to face masks, how they might impact public health policies, and how they should be considered in health...
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