Fabrication of PLGA/HA (core)-collagen/amoxicillin (shell) nanofiber membranes through coaxial electrospinning for guided tissue regeneration

Guided tissue regeneration (GTR) membranes are key materials used to create barriers between soft and bone tissues during bone defect repair; however, single-function barrier GTR membranes cannot meet clinical requirements. In this paper, we propose a GTR membrane with drug release, bone guidance, and barrier functions; this membrane is a poly(lactic-co-glycolic acid) (PLGA)/hydroxyapatite (HA) (core)-collagen/amoxicillin (shell) nanofiber...