Screening for Occult Cancer in Unprovoked Venous Thromboembolism

Published on Aug 19, 2015in The New England Journal of Medicine91.253
· DOI :10.1056/NEJMOA1506623
Marc Carrier60
Estimated H-index: 60
Alejandro Lazo-Langner26
Estimated H-index: 26
+ 16 AuthorsMarc A. Rodger80
Estimated H-index: 80
BackgroundVenous thromboembolism may be the earliest sign of cancer. Currently, there is a great diversity in practices regarding screening for occult cancer in a person who has an unprovoked venous thromboembolism. We sought to assess the efficacy of a screening strategy for occult cancer that included comprehensive computed tomography (CT) of the abdomen and pelvis in patients who had a first unprovoked venous thromboembolism. MethodsWe conducted a multicenter, open-label, randomized, controlled trial in Canada. Patients were randomly assigned to undergo limited occult-cancer screening (basic blood testing, chest radiography, and screening for breast, cervical, and prostate cancer) or limited occult-cancer screening in combination with CT. The primary outcome measure was confirmed cancer that was missed by the screening strategy and detected by the end of the 1-year follow-up period. ResultsOf the 854 patients who underwent randomization, 33 (3.9%) had a new diagnosis of occult cancer between randomizat...
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