Clinical risk factors of colorectal cancer in patients with serrated polyposis syndrome: a multicentre cohort analysis

Serrated polyposis syndrome (SPS) is accompanied by an increased risk of colorectal cancer (CRC). Patients fulfilling the clinical criteria, as defined by the WHO, have a wide variation in CRC risk. We aimed to assess risk factors for CRC in a large cohort of patients with SPS and to evaluate the risk of CRC during surveillance.In this retrospective cohort analysis, all patients with SPS from seven centres in the Netherlands and two in the UK...