Antibody–drug conjugates as novel anti-cancer chemotherapeutics
Abstract
Over the past couple of decades, antibody–drug conjugates (ADCs) have revolutionized the field of cancer chemotherapy. Unlike conventional treatments that damage healthy tissues upon dose escalation, ADCs utilize monoclonal antibodies (mAbs) to specifically bind tumour-associated target antigens and deliver a highly potent cytotoxic agent. The synergistic combination of mAbs conjugated to small-molecule chemotherapeutics, via a stable linker,...
Paper Details
Title
Antibody–drug conjugates as novel anti-cancer chemotherapeutics
Published Date
Jul 14, 2015
Journal
Volume
35
Issue
4
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