Original paper
Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis
Abstract
Obesity and extracellular matrix (ECM) density are considered independent risk and prognostic factors for breast cancer. Whether they are functionally linked is uncertain. We investigated the hypothesis that obesity enhances local myofibroblast content in mammary adipose tissue and that these stromal changes increase malignant potential by enhancing interstitial ECM stiffness. Indeed, mammary fat of both diet- and genetically induced mouse...
Paper Details
Title
Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis
Published Date
Aug 19, 2015
Volume
7
Issue
301
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Notes
History