Neonatal lupus erythematosus: a cutaneous cases based update

Published on Jan 7, 2016in Italian Journal of Pediatrics2.638
路 DOI :10.1186/S13052-015-0208-5
Francesco Savino37
Estimated H-index: 37
(Boston Children's Hospital),
S. Viola8
Estimated H-index: 8
(Boston Children's Hospital)
+ 3 AuthorsPaola Coppo4
Estimated H-index: 4
(Boston Children's Hospital)
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Abstract
Background Neonatal Lupus Erythematosus (NLE) is an uncommon autoimmune disease characterized by cutaneous, hepatic, hematological, neurological and cardiac involvement.
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References24
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#1Kateri LevesqueH-Index: 5
#2Nathalie MorelH-Index: 21
Last. Laurent Fermont (Necker-Enfants Malades Hospital)H-Index: 22
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Abstract Background Cardiac neonatal lupus syndrome is due to anti-SSA or SSB antibodies and mainly includes congenital heart block (CHB) and dilated cardiomyopathy (DCM). Its optimal management is still debated. We report a large series of autoimmune high degree CHB. Methods Inclusion criteria in this retrospective study were fetuses or neonates with high-degree CHB associated with maternal anti-SSA/SSB antibodies. Results 214 CHB were included: 202 detected in utero at a median term of 23聽week...
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#1Yi-qun Li (Academy of Medical Sciences, United Kingdom)H-Index: 1
#2Qian Wang (Peking Union Medical College Hospital)H-Index: 7
Last. Yan Zhao (Peking Union Medical College Hospital)H-Index: 28
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Aim To analyze the clinical features, outcomes and prognosis of neonatal lupus erythematosus (NLE) in China. Method We reviewed 12 NLE cases at the Peking Union Medical College Hospital and compared the data with 111 cases reported in China between 1990 and 2014. The Chinese medical journal search engines used in this study were Wanfang.data and Science China. Results No gender dominance in NLE incidence was found. Cutaneous lesions were present in more than 96% of patients, while cardiac, hemat...
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Objective: To study clinical manifestations, investigations, treatment and outcomes of neonatal lupus erythematosus (NLE)聽patients and their mothers. Material and Method: A retrospective descriptive study was performed to review the neonatal lupus erythematosus patients聽and their mothers at Queen Sirikit National Institute of Child Health during January 1993 to December 2013. The diagnostic聽criteria required the presence of clinical symptoms plus positive anti-Ro/SSA or anti-La/SSB or both. Resu...
#1Chueh-Tan Chen (Memorial Hospital of South Bend)H-Index: 6
#2K-L Lin (CGU: Chang Gung University)H-Index: 1
Last. J-L Huang (CGU: Chang Gung University)H-Index: 1
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Neonatal lupus is a rare and acquired autoimmune disease. Central nervous system abnormalities are potential manifestations in neonatal lupus. Through a systematic literature review, we analyzed the clinical features of previously reported neonatal lupus cases where central nervous system abnormalities had been identified. Most reported neonatal lupus patients with central nervous system involvement were neuroimaging-determined and asymptomatic. Only seven neonatal lupus cases were identified as...
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#1Rina Mina (Cincinnati Children's Hospital Medical Center)H-Index: 12
#2Hermine I. Brunner (Cincinnati Children's Hospital Medical Center)H-Index: 46
Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 23.2/100,000 in the United States. There is increasing understanding about differences in disease manifestations, medication use, and disease severity between those with childhood-onset SLE as compared with adult-onset SLE. Children have a more fulminant disease onset and course than adults with SLE,...
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Erythema multiforme (EM) is an uncommon, immune-mediated disorder that presents with cutaneous or mucosal lesions or both. In herpes simplex virus (HSV)鈥恆ssociated EM, the findings are thought to result from cell-mediated immune reaction against viral antigenpositive cells that contain the HSV DNA polymerase gene (pol). The target lesion, with concentric zones of color change, represents the characteristic cutaneous finding seen in this disorder. Although EM can be induced by various factors, HS...
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#1Martin Inzinger (University of Graz)H-Index: 2
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Last. Barbara Binder (Medical University of Graz)H-Index: 19
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Summary Neonatal lupus erythematosus (NLE) is a rare disease affecting newborns that is caused by maternal autoantibodies transmitted across the placenta. The disease may affect the skin, the heart, and rarely the hepatobiliary or hematological systems. A serious complication affecting some patients with NLE is atri-oventricular heart block (AV block). The clinical picture of cutaneous NLE varies considerably. NLE presents with confluent, scaly, periorbital erythema, or erythematous infiltrated ...
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#1Wanee Wisuthsarewong (MU: Mahidol University)H-Index: 2
#2Jarupim Soongswang (MU: Mahidol University)H-Index: 1
Last. Rattanavalai Chantorn (MU: Mahidol University)H-Index: 4
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Abstract: Neonatal lupus erythematosus is an uncommon maternal auto-antibody-associated disease characterized by cutaneous, cardiac, hepatic, hematological, neurological, and pulmonary involvement. A retrospective study was performed to review clinical manifestations, investigation results, outcomes of neonatal lupus erythematosus patients and their mothers at the Department of Pediatrics, Siriraj Hospital during 1993 to 2008. Seventeen neonatal lupus erythematosus patients (10 girls and seven b...
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Objective. Maternal anti-SSA/Ro or anti-SSB/La antibodies are associated with neonatal lupus erythematosus syndrome (NLES), especially congenital heart block (CHB), which may be associated with severe endocardial fibroelastosis (EFE) and dilated cardiomyopathy (DCM). A few reports have described severe EFE without CHB associated with anti-SSA/Ro antibodies, with a poor prognosis. EFE has also been observed in biopsies of DCM that had been considered idiopathic. These points, considered in associ...
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Purpose of reviewThis review discusses how inflammatory rheumatic diseases [rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus (SLE)] of the mother can influence the course of pregnancy and the development of the fetus. Antirheumatic drug therapy of the mother and strategies
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Atopic diseases, such as atopic dermatitis (AD), allergic asthma (AA), and allergic rhinitis (AR), are increasingly becoming a worldwide issue. This atopic triad originates at an early age and on a multifactorial basis, causing significant discomfort to susceptible individuals. The global case number is now reaching new highs, so exploring immune system regulation and its components is becoming critical. One cytokine, interleukin-32 (IL-32), is involved in inflammation and regulation of the immu...
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BACKGROUND Peripheral quantitative computed tomography (pQCT) is the current densitometric gold-standard for assessing skeletal muscle at the 66% proximal tibia site. High resolution peripheral quantitative computed tomography (HR-pQCT) is a leading technology for quantifying bone microarchitecture at the distal extremities, and with the second-generation HR-pQCT it is possible to measure proximal limb sites. Therefore, the objectives of this study were to: (1) assess the feasibility of using HR...
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Background Neonatal lupus erythematosus is an autoimmune disease acquired during fetal life as a result of transplacental passage of maternal anti-Sjogren's-syndrome-related antigen A (anti-SSA/Ro), anti-Sjogren's-syndrome-related antigen B (anti-SSB/La) or anti-U1 ribonucleoprotein (anti-U1-RNP) antinuclear autoantibodies. Contents Clinical manifestations include skin lesions, congenital heart block, hepatobiliary involvement and cytopenias. Most of the disorders disappear spontaneously after c...
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To explore the clinical features, autoantibodies, and outcome of neonatal lupus erythematosus (NLE). Methods: We retrospectively reviewed all NLE cases from January 2012 to May 2019 that occurred i...
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1. Joseph S. Tadros, MD* 2. Yang Yu, MD鈥 3. Anne W. Lucky, MD鈥,鈥 1. *University of Cincinnati College of Medicine, Cincinnati, OH 2. 鈥燚epartment of Dermatology, University of Cincinnati Medical Center, Cincinnati, OH 3. 鈥ivision of General and Community Pediatrics, Cincinnati Children鈥檚 Hospital, Cincinnati, OH A previously healthy, full-term, 3-month-old girl presents with several annular erythematous patches and plaques on the head, scalp, and upper body. The lesions first appeared at 6 weeks...
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