Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate
Volume: 304, Issue: 6, Pages: G597 - G604
Published: Mar 15, 2013
Abstract
Uridine diphosphate (UDP) is a proinflammatory nucleotide implicated in inflammatory bowel disease. Intestinal alkaline phosphatase (IAP) is a gut mucosal defense factor capable of inhibiting intestinal inflammation. We used the malachite green assay to show that IAP dephosphorylates UDP. To study the anti-inflammatory effect of IAP, UDP or other proinflammatory ligands (LPS, flagellin, Pam3Cys, or TNF-α) in the presence or absence of IAP were...
Paper Details
Title
Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate
Published Date
Mar 15, 2013
Volume
304
Issue
6
Pages
G597 - G604
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