Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Abstract
Pathological expansion of adipose tissue contributes to the metabolic syndrome. Distinct depots develop at various times under different physiological conditions. The transcriptional cascade mediating adipogenesis is established in vitro, and centres around a core program involving PPARγ and C/EBPα. We developed an inducible, adipocyte-specific knockout system to probe the requirement of key adipogenic transcription factors at various stages of...
Paper Details
Title
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Published Date
Aug 17, 2015
Journal
Volume
17
Issue
9
Pages
1099 - 1111
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