Philipp E. Scherer
University of Texas Southwestern Medical Center
AdipogenesisEndocrinologyWhite adipose tissueAdipose tissueChemistryAdipokineAdipocyteAdiponectinInflammationType 2 diabetesInsulin resistanceInsulinCaveolinLeptinCaveolaeBiochemistryDiabetes mellitusMedicineBiologyCell biology
563Publications
149H-index
67.4kCitations
Publications 542
Newest
#1Jessica Cannavino (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
#2Mengle Shao (UTSW: University of Texas Southwestern Medical Center)H-Index: 25
Last. Eric N. Olson (UTSW: University of Texas Southwestern Medical Center)H-Index: 230
view all 13 authors...
Homeothermic vertebrates produce heat in cold environments through thermogenesis, in which brown adipose tissue (BAT) increases mitochondrial oxidation along with uncoupling of the electron transport chain and activation of uncoupling protein 1 (UCP1). Although the transcription factors regulating the expression of UCP1 and nutrient oxidation genes have been extensively studied, only a few other proteins essential for BAT function have been identified. We describe the discovery of FAM195A, a BAT...
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#1Rong Yang (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
#2Eunice E. Lee (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
Last. Richard C. Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 23
view all 18 authors...
Circular RNAs (circRNAs) are a conserved class of RNAs with diverse functions, including serving as messenger RNAs that are translated into peptides. Here we describe circular RNAs generated by human polyomaviruses (HPyVs), some of which encode variants of the previously described alternative large T antigen open reading frame (ALTO) protein. Circular ALTO RNAs (circALTOs) can be detected in virus positive Merkel cell carcinoma (VP-MCC) cell lines and tumor samples. CircALTOs are stable, predomi...
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#1Na Li (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
#2Shangang Zhao (UTSW: University of Texas Southwestern Medical Center)H-Index: 16
Last. Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
view all 20 authors...
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process an...
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#1Na Li (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
#2Shangang Zhao (UTSW: University of Texas Southwestern Medical Center)H-Index: 16
Last. Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
view all 21 authors...
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#1Kezia Lizardo (Hackensack University Medical Center)
#2Janeesh Plakkal Ayyappan (UoK: University of Kerala)H-Index: 1
Last. Jyothi F. Nagajyothi (Hackensack University Medical Center)H-Index: 8
view all 6 authors...
Chronic Chagas cardiomyopathy (CCC) caused by a parasite Trypanosoma cruzi is a life-threatening disease in Latin America, for which there is no effective drug or vaccine. The pathogenesis of CCC is complex and multifactorial. Previously, we demonstrated T. cruzi infected mice lose a significant amount of fat tissue which correlates with progression of CCC. Based on this an investigation was undertaken during both acute and chronic T. cruzi infection utilizing the FAT-ATTAC murine model (that al...
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#1Nolwenn Joffin (UTSW: University of Texas Southwestern Medical Center)H-Index: 9
#2Vivian A. Paschoal (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
Last. Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
view all 13 authors...
Summary The adipose tissue stroma is a rich source of molecularly distinct stem and progenitor cell populations with diverse functions in metabolic regulation, adipogenesis, and inflammation. The ontology of these populations and the mechanisms that govern their behaviors in response to stimuli, such as overfeeding, however, are unclear. Here, we show that the developmental fates and functional properties of adipose platelet-derived growth factor receptor beta (PDGFRβ)+ progenitor subpopulations...
3 CitationsSource
#1Toshiharu Onodera (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
#2Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
Summary Apoptosis repressor with caspase recruitment domain (ARC) is an established cytoplasmic anti-apoptotic factor relevant for cancer and metabolic disease. In this issue of Developmental Cell, McKimpson et al. show that ARC can assume potent pro-apoptotic effects in β cells of the endocrine pancreas via translocation to the nucleus.
1 CitationsSource
#1Yu An (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
#2Shiuhwei Chen (UTSW: University of Texas Southwestern Medical Center)H-Index: 12
Last. Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
view all 12 authors...
Abstract Background & Aims We have previously reported that the mitochondrial dicarboxylate carrier (mDIC) is predominantly expressed in the white adipose tissue (WAT) and subject to regulation by metabolic cues. The specific physiological functions of mDIC and the reasons for its abundant presence in adipocytes are however poorly understood. Methods To systemically investigate the impact of mDIC function in adipocytes in vivo, we generated loss- and gain-of-function mouse models, selectively el...
1 CitationsSource
#1Shiuhwei Chen (UTSW: University of Texas Southwestern Medical Center)H-Index: 12
#2Zhijiang Huang (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
Last. Wen Hong Li (UTSW: University of Texas Southwestern Medical Center)H-Index: 27
view all 11 authors...
Appropriate insulin secretion is essential for maintaining euglycemia, and impairment or loss of insulin release represents a causal event leading to diabetes. There have been extensive efforts of studying insulin secretion and its regulation using a variety of biological preparations, yet it remains challenging to monitor the dynamics of insulin secretion at the cellular level in the intact pancreas of living animals, where islet cells are supplied with physiological blood circulation and oxyge...
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#1May-Yun Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
#1May-Yun Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 32
Last. William L. Holland (UTSW: University of Texas Southwestern Medical Center)H-Index: 40
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We evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor (Ab-4) to maintain glucose homeostasis in type 1 diabetic rodents. We noted durable and sustained improvements in glycemia which persist long after treatment withdrawal. Ab-4 promoted β-cell survival and enhanced the recovery of insulin+ islet mass with concomitant increases in circulating insulin and C peptide. In PANIC-ATTAC mice, an inducible model of β-cell apoptosis which allows for robust assessment of...
1 CitationsSource