Original paper
Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy
Abstract
Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance. Here, we perform a screen with a library of clinically used drug molecules for their effects on cell size. We find that statins, inhibitors of the mevalonate pathway, reduce cell proliferation and increase cell size and cellular protein density in various cell types,...
Paper Details
Title
Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy
Published Date
Dec 1, 2015
Journal
Volume
13
Issue
11
Pages
2610 - 2620
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Notes
History