Function of TGF-beta and p38 MAKP signaling pathway in osteoblast differentiation from rat adipose-derived stem cells.

Adipose-derived stem cells (ADSCs) are multipotent progenitors that can commit to osteoblast, chondrocyte, adipocyte and several other lineages. The proper utilization of stem cells for clinical application requires an integrated understanding of multiple signal inputs that control maintenance of stemness, proliferation and differentiation.In this study, ADSCs in rat were isolated from subcutaneous tissues of abdomen and inguinal fat pads,...