Plasma levels of thrombomodulin, plasminogen activator inhibitor-1 and fibrinogen in elderly, diabetic patients with depressive symptoms.

Published on Oct 1, 2016in Aging Clinical and Experimental Research2.697
· DOI :10.1007/S40520-015-0504-3
Małgorzata Górska-Ciebiada10
Estimated H-index: 10
(Medical University of Łódź),
Małgorzata Saryusz-Wolska12
Estimated H-index: 12
(Medical University of Łódź)
+ 2 AuthorsJerzy Loba14
Estimated H-index: 14
(Medical University of Łódź)
Background Diabetes, depression and aging have been associated with pro-inflammatory and prothrombotic state.
📖 Papers frequently viewed together
4 Authors (A. J. Simpson, ..., R. S. Gray)
7 Citations
12 Citations
#1Małgorzata Górska-Ciebiada (Medical University of Łódź)H-Index: 10
#2Małgorzata Saryusz-Wolska (Medical University of Łódź)H-Index: 12
Last. Jerzy Loba (Medical University of Łódź)H-Index: 14
view all 5 authors...
Objective The aim of the study was to determine the serum levels of CRP, IL-6 and TNF-α in elderly diabetic patients with depressive syndrome alone or with coexisting mild cognitive impairment (MCI).
40 CitationsSource
#1Małgorzata Górska-Ciebiada (Medical University of Łódź)H-Index: 10
#2Małgorzata Saryusz-Wolska (Medical University of Łódź)H-Index: 12
Last. Jerzy Loba (Medical University of Łódź)H-Index: 14
view all 4 authors...
The aim of the study was to estimate the prevalence of mild cognitive impairment (MCI), depressive syndrome cases, and its comorbidity, and to identify predictors of these conditions. Methods. 276 diabetics elders were screened for MCI and depressive symptoms. Detailed information of history of diabetes, and data of BMI, HbA1c, and blood lipids were collected. Results. The prevalence of MCI was 31.5%, depressive syndrome was 29.7%, and MCI with coexisting depressive mood was 9.1%. The logistic r...
48 CitationsSource
#1T. Van Sloten (Maastricht University Medical Centre)H-Index: 4
#2Miranda T. Schram (Maastricht University Medical Centre)H-Index: 40
Last. Ronald M.A. Henry (Maastricht University Medical Centre)H-Index: 38
view all 11 authors...
Background Endothelial dysfunction (ED), low-grade inflammation (LGI) and oxidative stress (OxS) may be involved in the pathobiology of depression. Previous studies on the association of these processes in depression have yielded contradictory results. We therefore investigated comprehensively, in a population-based cohort study, the association between ED, LGI and OxS on the one hand and depressive symptoms on the other. Method We used data from the Hoorn Study and determined biomarkers of ED [...
38 CitationsSource
#1Hyun Kyung Kim (SNU: Seoul National University)H-Index: 21
#2Ji-Eun Kim (SNU: Seoul National University)H-Index: 56
Last. Eun Sook Kim (UOU: University of Ulsan)H-Index: 11
view all 6 authors...
Abstract Aims A prothrombotic state characterized by activation of the coagulation system has been implicated in the pathogenesis of vascular complications in diabetes mellitus. Recently, a thrombin generation assay was introduced as a laboratory assessment of global hemostatic potential. We used this thrombin generation assay to investigate global hemostatic potential in patients with diabetes who did not have macrovascular complications. Methods This study was a prospective case–control study ...
35 CitationsSource
#1Waleed M. Sweileh (An-Najah National University)H-Index: 32
Last. Sa’ed H. Zyoud (An-Najah National University)H-Index: 30
view all 4 authors...
Background: Diabetes mellitus is a common chronic metabolic disorder and one of the main causes of death in Palestine. Palestinians are continuously living under stressful economic and military conditions which make them psychologically vulnerable. The purpose of this study was to investigate the prevalence of depression among type II diabetic patients and to examine the relationship between depression and socio-demographic factors, clinical factors, and glycemic control. Methods: This was a cro...
60 CitationsSource
#1Todd Doyle (OU: Ohio University)H-Index: 8
#2Mary de Groot (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 24
Last. Alka M. Kanaya (UCSF: University of California, San Francisco)H-Index: 70
view all 7 authors...
Objective Up-regulated levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) are common to both type 2 diabetes mellitus (T2DM) and elevated depressive symptoms, yet little attention has been given to the biological mechanisms associated with these co-morbidities. This study examined the association between inflammation and both T2DM and elevated depressive symptoms.
37 CitationsSource
#1Dimitris Tousoulis (Athens State University)H-Index: 81
#2Nikolaos Papageorgiou (Athens State University)H-Index: 25
Last. Christodoulos Stefanadis (Athens State University)H-Index: 118
view all 7 authors...
It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase activity as well as enhances the production of reactive oxygen species, thus resulting in diminished nitric oxide bioavailability and the consequent pro-atherogenetic alterations. Important biomarkers of the vasculature are related to endothelial dysfunction, to inflammatory and coagulation processes, and to oxidative stress in DM. Several therapeutic strategies might exert favorable effects on the vascul...
190 CitationsSource
#1Marie Kim Wium-Andersen (UCPH: University of Copenhagen)H-Index: 12
#2David Dynnes Ørsted (UCPH: University of Copenhagen)H-Index: 15
Last. Børge G. NordestgaardH-Index: 158
view all 3 authors...
Association between elevated plasma fibrinogen and psychological distress, and depression in 73 367 individuals from the general population
10 CitationsSource
#1Kannayiram Alagiakrishnan (U of A: University of Alberta)H-Index: 20
#2Nancy Zhao (U of A: University of Alberta)H-Index: 1
Last. Ambikaipakan Senthilselvan (U of A: University of Alberta)H-Index: 52
view all 5 authors...
Aim. This study compares the usefulness of Montreal Cognitive Assessment (MoCA) to Standardized Mini-Mental Status Exam (SMMSE) for diagnosing mild cognitive impairment (MCI) in Type 2 diabetes mellitus (DM) population. Methods. This prospective pilot study enrolled 30 community dwelling adults with Type 2 DM aged 50 years and above. Subjects were assessed using both the SMMSE and MoCA for MCI. In all subjects, depression and dementia were ruled out using the DSM IV criteria, and a functional as...
74 CitationsSource
#1Michael J Stuart (JCU: James Cook University)H-Index: 6
#2Bernhard T. Baune (University of Adelaide)H-Index: 95
Unipolar depression and diabetes mellitus each account for a significant proportion of the global burden of disease. Epidemiological literature suggests a bi-directional relationship between these two common disorders, and evidence from the molecular sciences supports a role for inflammation in the pathogenesis and pathophysiology of each disorder individually. Recent advances in understanding the neurobiology of depression have implicated dysfunction of the hypothalamus–pituitary–adrenal axis, ...
163 CitationsSource
Cited By10
#1Alistair L. Carr (Edin.: University of Edinburgh)
#2Anniek J. Sluiman (Edin.: University of Edinburgh)H-Index: 1
Last. Jackie F. Price (Edin.: University of Edinburgh)H-Index: 4
view all 7 authors...
Aims/hypothesis We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship. Methods The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-75 years. Cox proportional hazards regression analysis was used to investigate the association between depression, assessed at baseline, and subsequent risk of dementia over 10 year...
#1Giuseppe Fanelli (UNIBO: University of Bologna)H-Index: 2
#2Francesco BenedettiH-Index: 68
Last. Chiara Fabbri ('KCL': King's College London)H-Index: 25
view all 11 authors...
Depression affects 7% of the elderly population, and it often remains misdiagnosed or untreated. Peripheral biomarkers might aid clinicians by allowing more accurate and well-timed recognition of the disease. We sought to determine if plasma protein levels predict the severity of depressive symptomatology or distinguish patients from healthy individuals. The severity of depressive symptoms and global cognitive functioning were assessed by the Geriatric Depression Scale (GDS) and Mini-Mental Stat...
#1Abdel G. Elkahloun (NIH: National Institutes of Health)H-Index: 67
#2Juan M. Saavedra (GUMC: Georgetown University Medical Center)H-Index: 19
Last. Juan M. Saavedra (GUMC: Georgetown University Medical Center)H-Index: 98
view all 2 authors...
Preclinical experiments and clinical trials demonstrated that angiotensin II AT1 receptor overactivity associates with aging and cellular senescence and that AT1 receptor blockers (ARBs) protect from age-related brain disorders. In a primary neuronal culture submitted to glutamate excitotoxicity, gene set enrichment analysis (GSEA) revealed expression of several hundred genes altered by glutamate and normalized by candesartan correlated with changes in expression in Alzheimer’s patient’s hippoca...
9 CitationsSource
#1Xiaohui Wang (HFH: Henry Ford Hospital)H-Index: 2
#2Rongwen Li (HFH: Henry Ford Hospital)H-Index: 3
Last. Xu Cui (HFH: Henry Ford Hospital)H-Index: 31
view all 7 authors...
Diabetes leads to an elevated risk of stroke and worse functional outcome compared to the general population. We investigate whether L-4F, an economical ApoA-I mimetic peptide, reduces neurovascular and white-matter damage in db/db type-2 diabetic (T2DM) stroke mice. L-4F (16 mg/kg, subcutaneously administered initially 2 h after stroke and subsequently daily for 4 days) reduced hemorrhagic transformation, decreased infarct-volume and mortality, and treated mice exhibited increased cerebral arte...
4 CitationsSource
#1Hong PanH-Index: 1
#2Ying ZhaoH-Index: 3
Last. Lian-Dong ZhaoH-Index: 2
view all 9 authors...
: Parkinson's disease is a neurodegenerative disease that frequently results in memory disorders, cognitive decline and dementia. Previous studies have reported that plasminogen activator inhibitor-1 (PAI-1) serves an important role in cardiovascular disease risk, adiposity, insulin resistance and inflammation. However, the role of PAI-1 in diagnosis and prognosis of patients with Parkinson's disease following deep brain stimulation (DBS) has not reported, to the best of our knowledge. Therefore...
7 CitationsSource
#1Douglas E. Vaughan (NU: Northwestern University)H-Index: 85
#2Rahul Rai (NU: Northwestern University)H-Index: 7
Last. Asish K. Ghosh (NU: Northwestern University)H-Index: 30
view all 5 authors...
PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cel...
80 CitationsSource
#1Nicholas J. Ashton (Centre for Mental Health)H-Index: 21
#2Abdul Hye (Centre for Mental Health)H-Index: 24
Last. Natalie L. Marchant (UCL: University College London)H-Index: 20
view all 10 authors...
The repressor element 1-silencing transcription (REST) factor is a key regulator of the aging brain’s stress response. It is reduced in conditions of stress and Alzheimer’s disease (AD), which suggests that increasing REST may be neuroprotective. REST can be measured peripherally in blood plasma. Our study aimed to (1) examine plasma REST levels in relation to clinical and biological markers of neurodegeneration and (2) alter plasma REST levels through a stress-reduction intervention—mindfulness...
21 CitationsSource
#1Xiaoqian LuanH-Index: 2
#2Huiping ShenH-Index: 5
Last. Jincai HeH-Index: 1
view all 6 authors...
Abstract Background: Post-stroke depression (PSD) is a disease with high incidence in stroke patients. It is reported that about one third of stroke patients may develop depression after stroke. Elevated levels of plasma fibrinogen are found in stroke patients. Our study aims to find out whether there is a relationship between plasma fibrinogen level and PSD. Methods and Findings: 406 acute ischemic stroke patients were admitted to our study. Plasma fibrinogen levels were assayed at hospital adm...
2 CitationsSource
#1Tilahun Belete Mossie (College of Health Sciences, Bahrain)H-Index: 3
Last. Minale Tareke (Bahir Dar University)H-Index: 6
view all 4 authors...
Background: Coexistence of mental health problems on diabetes mellitus can result in poor management of the illness, poor adherence to treatment, and low quality of life. Therefore, it is highly crucial to assess these problems; thus we carried out this study with the aim of determining the prevalence of depression and identifying related factors among diabetic patients at city of Mekelle, North Ethiopia. Methods: Hospital-based cross-sectional study was employed among 264 diabetic patients, and...
14 CitationsSource
#1Man K. Chan (University of Cambridge)H-Index: 14
#2Jason D. Cooper (University of Cambridge)H-Index: 54
Last. Sabine Bahn (University of Cambridge)H-Index: 70
view all 10 authors...
Antidepressant treatment for major depressive disorder remains suboptimal with response rates of just over 50%. Although treatment guidelines, algorithms and clinical keys are available to assist the clinician, the process of finding an effective pharmacotherapy to maximise benefit for the individual patient is largely by “trial and error” and remains challenging. This highlights a clear need to identify biomarkers of treatment response to help guide personalised treatment strategies. We have ca...
15 CitationsSource