Original paper
Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer
Abstract
Metabolic reprogramming is a hallmark of cancer. Oncogenic growth signaling regulates glucose, glutamine and lipid metabolism to meet the bioenergetics and biosynthetic demands of rapidly proliferating tumor cells. Emerging evidence indicates that sterol regulatory element-binding protein 1 (SREBP-1), a master transcription factor that controls lipid metabolism, is a critical link between oncogenic signaling and tumor metabolism. We recently...
Paper Details
Title
Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer
Published Date
May 12, 2014
Volume
20
Issue
15
Pages
2619 - 2626
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Notes
History