Current Pharmaceutical Design
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#1Mayank Sharma (Narsee Monjee Institute of Management Studies)H-Index: 1
#2Simran Waghela (Narsee Monjee Institute of Management Studies)
Last. Gaurav K. SaraogiH-Index: 9
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Proteins and hormones have a wide range of therapeutic uses that have emerged throughout the years. The increase in their clinical application nowadays have outgrown the need to deliver these macromolecules without deterioration and ease of administration, therefore nasal delivery has proven to be the most useful tool. Despite the obstacles, smart polymers, nasal enhancers, nanotechnology-based delivery systems, and computational modelling tools have all been used to increase the residence time ...
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#1Sana Kalave (Narsee Monjee Institute of Management Studies)
#2Bappaditya Chatterjee (Narsee Monjee Institute of Management Studies)H-Index: 16
Last. Ambikanandan Misra (Narsee Monjee Institute of Management Studies)H-Index: 1
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Skin being the largest external organ, offers an enticing procedure for transdermal drug delivery, so the drug needs to rise above the outermost layer of the skin, i.e., stratum corneum. Small molecular drug entities obeying the Lipinski rule, i.e., drugs having a molecular weight less than 500Da, high lipophilicity, and optimum polarity, are favored enough to be used on the skin as therapeutics. Skin's barrier action properties prevent the transport of macromolecules at pre-determined therapeut...
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#1Wen Xu (CTGU: China Three Gorges University)H-Index: 2
#2Bei Wang (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
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BACKGROUND Long noncoding RNA (lncRNA) fetal-lethal non-coding developmental regulatory RNA (FENDRR), a newly known lncRNA, has been reported to be abnormally expressed in diverse tumors. This review is focused on clarifying the mechanism of FENDRR to regulate the biological process of tumors, affirming its value as a target for tumor therapy. METHODS The pathophysiological mechanism of FENDRR acting on tumors has been analyzed and summarized by reviewing PubMed. RESULTS The expression of lncRNA...
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#1Arash Heidari (Education and Research Network)
#2Pouya Mahdavi Sharif (Education and Research Network)
Last. Nima Rezaei (Tehran University of Medical Sciences)H-Index: 80
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Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults, causing many deaths each year. The life expectancy of patients from the time of diagnosis does not exceed 15 months. Tumoral cells are generally surrounded by a bed of tumor microenvironment (TME), composed of various components such as different immune cells, stromal cells, and blood vessels. Previous studies on the treatment of this tumor have generally focused on cancerous cells and therefore, have introduced co...
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#1Chengyu Hu (CTGU: China Three Gorges University)H-Index: 2
#2Wen Xu (CTGU: China Three Gorges University)H-Index: 2
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 13
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BACKGROUND Long non-coding RNAs (lncRNAs) has no protein-coding potential due to the lack of an apparent open reading frame. There is growing evidence that lncRNA DGCR5 has a vital regulatory role in human illnesses' pathological development, particularly in the digestive system's carcinogenesis and progression. Abnormal DGCR5 expression affects different cellular functions such as proliferation, aggression, and metastasis. This paper aims to probe into the pathophysiological functions and molec...
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#1N. Kruijt (Radboud University Nijmegen)H-Index: 1
#2Luuk R van den Bersselaar (Radboud University Nijmegen)H-Index: 1
Last. Nicol C. Voermans (Radboud University Nijmegen)H-Index: 24
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Variants in the ryanodine receptor-1 gene (RYR1) have been associated with a wide range of neuromuscular conditions, including various congenital myopathies and malignant hyperthermia (MH). More recently, a number of RYR1 variants, mostly MH-associated, have been demonstrated to contribute to rhabdomyolysis events not directly related to anesthesia in otherwise healthy individuals. This review focuses on RYR1-related rhabdomyolysis, in the context of several clinical presentations (i.e., exertio...
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#1Gowhar Ahmad NaikooH-Index: 10
Last. Abdullah M. Asiri (KAU: King Abdulaziz University)H-Index: 125
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In this review, we summarised the different methods for copper nanoparticle synthesis, including green methods. We highlighted that the synthesis of the copper nanoparticles from green sources is preferable as they serve as stable and reducing entities. Furthermore, we critically reviewed the effectiveness of copper-based nanoparticles in oncogenic treatments emphasizing breast, lung, colorectal, and skin cancers. Finally, we have summarised the recent progress made in copper-based nanoparticles...
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#1Poonam Parashar (BBAU: Babasaheb Bhimrao Ambedkar University)H-Index: 8
#2Neelu Singh (BBAU: Babasaheb Bhimrao Ambedkar University)H-Index: 2
Last. Shubhini A. Saraf (BBAU: Babasaheb Bhimrao Ambedkar University)H-Index: 21
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Nanoparticles (NPs) as nanocarriers have emerged as novel and promising theranostic agents. The term theranostics revealed the properties of NPs capable of diagnosing the disease at an early stage and/or treating the disease. Such NPs are usually developed employing a surface engineering approach. The theranostic agents comprise NPs loaded with a drug/diagnostic agent that delivers it precisely to the target site. Theranostics is a field with promising results in enhancing therapeutic efficacy f...
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#1Andrea Amerio (UniGe: University of Genoa)H-Index: 9
#2Costanza Giacomini (UniGe: University of Genoa)
Last. Mario Amore (UniGe: University of Genoa)H-Index: 59
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Lurasidone is a novel azapirone derivative, and atypical antipsychotic agent with a high binding affinity for dopaminergic (D2), serotoninergic (5-HT2A), and 5-HT7 receptors (antagonist), a moderate affinity for 5-HT1A receptors (partial agonist), and no appreciable affinity for histaminergic (H1) and muscarinic (M1) receptors. It was recently included by the European Medication Agency among the in-label pharmacological treatments for children and adolescents affected by early onset schizophreni...
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