Current Pharmaceutical Design
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3.12
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9,398
Papers 9,351
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#1Juan B. De Sanctis (Palacký University, Olomouc)H-Index: 19
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#1Shweta Dang (JIIT: Jaypee Institute of Information Technology)H-Index: 17
#2Sanjula Baboota (Jamia Hamdard)H-Index: 54
Last. Javed Ali (Jamia Hamdard)H-Index: 70
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#1Camila Correa (UFRGS: Federal University of Rio Grande do Sul)H-Index: 8
#2Patrícia Bieger (UFRGS: Federal University of Rio Grande do Sul)
Last. Gabriela C. Souza (UFRGS: Federal University of Rio Grande do Sul)H-Index: 8
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BACKGROUND Sarcopenia is a progressive and generalized skeletal muscle disorder with unfavorable muscle changes throughout life, which can be associated with chronic disease. Testosterone supplementation is emerging as a possible therapy; however, it is still necessary to explore its effectiveness Objectives: This systematic review and meta-analysis aimed to evaluate and summarize the evidence related to the effect of testosterone supplementation on sarcopenia components of chronic disease patie...
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#1Shweta Goyal (ITRC: Indian Institute of Toxicology Research)H-Index: 3
#2Brashket Seth (ITRC: Indian Institute of Toxicology Research)H-Index: 8
Last. Rajnish Kumar Chaturvedi (ITRC: Indian Institute of Toxicology Research)H-Index: 30
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Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS) are neurological disorders, pathologically characterized by chronic degeneration of dopaminergic neurons and motor neurons respectively. There is still no cure or effective treatment against the disease progression and most of the treatments are symptomatic. The present review offers an overview of the different factors involved in the pathogenesis of these diseases. Subsequently, we focused on the recent advanced studies of dietar...
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BACKGROUND Over the past few years, an emerging number of new psychoactive substances (NPSs) entered the illicit market. NPSs are designed to resemble the effects of classical drugs of abuse, reinforcing their effects and duration. Among the most abused NPS, synthetic cannabinoids are cannabinoid receptor agonists (SCRAs) and mimic the effect of the main psychotropic phytocannabinoid Δ9-tetrahydrocannabinol (THC). METHODS We herein reviewed the international literature to provide available infor...
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#1Jonathan Koslowsky (Jacobi Medical Center)
#2Amit M Kakkar (Jacobi Medical Center)H-Index: 1
Last. Seth I. Sokol (Jacobi Medical Center)H-Index: 11
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Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality. Patients with PE can present with a wide array of symptoms, ranging from mild to life threatening. The mainstay of PE treatment is anticoagulation; however, there are many advanced options available for more severe patients, including catheter-directed interventions, surgical treatments, and hemodynamic support. Although different risk scores and clinical guidelines exist, the primary treating teams are frequently le...
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#1Stefanie Glaubitz (GAU: University of Göttingen)H-Index: 3
#2Rachel Zeng (GAU: University of Göttingen)H-Index: 2
Last. Jens Schmidt (GAU: University of Göttingen)H-Index: 23
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Inflammatory myopathies, in short, myositis, are heterogeneous disorders that are characterized by inflammation of skeletal muscle and weakness of arms and legs. Research over the past few years has led to a new understanding regarding the pathogenesis of myositis. The new insights include different pathways of the innate and adaptive immune response during the pathogenesis of myositis. The importance of non-inflammatory mechanisms such as cell stress and impaired autophagy has been recently des...
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#1Rishi Paliwal (IGNTU: Indira Gandhi National Tribal University)H-Index: 24
#2Pramod KumarH-Index: 11
Last. Shivani Rai Paliwal (GGU: Guru Ghasidas Vishwavidyalaya)H-Index: 17
view all 6 authors...
BACKGROUND Nanopharmaceuticals serve as emerging forms of modern medicines which include nanomedicines, nanosimilars, nanotheranostics, nanodevices and many more. In last two decades, a large number of nano-based products has reached to the market and are being used clinically. OBJECTIVES Unlike, conventional pharmaceutical products, nanopharmaceuticals behave differently both in vitro and in vivo and therefore, development of their generic versions needs special attention to replicate the simil...
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#1Faiza Idris Himasa (DITU: Dehradun Institute of Technology University)
#2Manmohan Singhal (DITU: Dehradun Institute of Technology University)H-Index: 1
Last. Bhavna Kumar (DITU: Dehradun Institute of Technology University)H-Index: 1
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Diabetic retinopathy is posterior eye disorder in which a damage occurs to the light sensitive retina due to diabetes mellitus, and affects people aged 18 - 64 with type ІІ diabetes. This disease progresses through different pathophysiological pathways. This includes oxidative stress, inflammation, stimulation of the growth factor in the eye's vasculature, isoforms of protein kinase C, and also the activation of the hexosamine pathway. It starts as micro aneurysms and advances in complicated sta...
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#1Bharti Rajesh Kumar Shyamlal (MNIT: Malaviya National Institute of Technology Jaipur)H-Index: 6
#2Manas Mathur (SGVU: Gyan Vihar University)H-Index: 2
Last. Sandeep Chaudhary (MNIT: Malaviya National Institute of Technology Jaipur)H-Index: 20
view all 7 authors...
BACKGROUND Several natural/synthetic molecules having structure similar to 1H-isochromen-1-ones have been reported to display promising antioxidants and platelet aggregation inhibitory activity. Isocoumarin (1H-2-benzopyran-1-one) skeleton, either whole or as a part of molecular framework, have been explored for their antioxidant or antiplatelet activities. INTRODUCTION Based on literature, a new prototype i.e., 3-phenyl-1H-isochromen-1-ones based compounds have been rationalized to possess both...
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