The Role of ROS in Ionizing Radiation-Induced VLA-4 Mediated Adhesion of RAW264.7 Cells to VCAM-1 Under Flow Conditions

Alteration of adhesion molecule expression on endothelial cells has a direct connection with ionizing radiation-induced atherosclerosis, which is an adverse effect observed after radiotherapy. However, minimal attention has been given to monocytes/macrophages role in atherosclerosis development, which are exposed to the radiation at the same time. Under flow conditions using a parallel plate flow chamber to mimic physiological shear stress, we...