Radiation Research
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#1Narongchai Autsavapromporn (CMU: Chiang Mai University)H-Index: 9
#2Alisa KobayashiH-Index: 9
Last. Teruaki KonishiH-Index: 18
view all 7 authors...
Radiation-induced bystander effect (RIBE) has been identified as an important contributing factor to tumor resistance and normal tissue damage. However, the RIBE in cancer and normal cells under hypoxia remain unclear. In this study, confluent A549 cancer and WI-38 normal cells were subjected to condition of hypoxia or normoxia, before exposure to high-LET protons microbeam. After 6 h incubation, cells were harvested and assayed for colony formation, micronucleus formation, chromosome aberration...
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#1Elizabeth A. Ainsbury (PHE: Public Health England)H-Index: 24
#2Claudia DalkeH-Index: 18
Last. Nobuyuki Hamada (CRIEPI: Central Research Institute of Electric Power Industry)H-Index: 34
view all 10 authors...
Recent epidemiological and experimental animal data, as well as reanalyses of data previously accumulated, indicate that the lens of the eye is more radiosensitive than was previously thought. This has resulted in a reduction of the occupational lens dose limit within the European Union countries, Japan and elsewhere. This Commentary introduces the work done by the LDLensRad Consortium contained within this Focus Issue, towards advancement of understanding of the mechanisms of low dose radiation...
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#1Jean A. Laissue (University of Bern)H-Index: 70
#2Sébastien F. Barré (University of Bern)H-Index: 8
Last. Raphaël Serduc (French Institute of Health and Medical Research)H-Index: 22
view all 13 authors...
Microbeam radiation therapy, an alternative radiosurgical treatment under preclinical investigation, aims to safely treat muzzle tumors in pet animals. This will require data on the largely unknown radiation toxicity of microbeam arrays for bones and teeth. To this end, the muzzle of six young adult New Zealand rabbits was irradiated by a lateral array of microplanar beamlets with peak entrance doses of 200, 330 or 500 Gy. The muzzles were examined 431 days postirradiation by computed microtomog...
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#1Carli B. Jones (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
#2Lauren B. Peiffer (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
Last. Karen S. Sfanos (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 12
view all 4 authors...
Beyond low-Earth orbit, space radiation poses significant risks to astronaut health. Previous studies have shown that the microbial composition of the gastrointestinal (GI) microbiome changes upon exposure to high-linear energy transfer radiation. Interestingly, radiation-induced shifts in GI microbiota composition are linked to various neuropsychological disorders. Herein, we aimed to study changes in GI microbiota and behaviors of rats exposed to whole-body radiation (0, 5 or 25 cGy 4He, 250 M...
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#1R. Cosar (Trakya University)H-Index: 3
#2Alaattin Özen (Trakya University)H-Index: 6
Last. Zafer Kocak (Trakya University)H-Index: 18
view all 10 authors...
Several studies have reported differences in radiation toxicity between the sexes, but these differences have not been tested with respect to histopathology and genes. This animal study aimed to show an association between histopathological findings of radiation-induced lung toxicity and the genes ATM, SOD2, TGF-β1, XRCC1, XRCC3 and HHR2. In all, 120 animals were randomly divided into 2 control groups (male and female) and experimental groups comprising fifteen rats stratified by sex, radiothera...
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The aim of this study was to examine the protective and/or mitigative properties of resveratrol (RSV) administered before or after irradiation of human lymphocytes in vitro. The isolated lymphocytes were incubated for 1 h with resveratrol, at doses of 0.1 (lowest), 0.5 (medium) or 1 (highest) mM/ml: 1 h before; immediately before; immediately after irradiation; and 1 h after irradiation with 0.5, 1 and 2 Gy. The degree of DNA damage was evaluated by Comet Assay. Treatment of human lymphocytes wi...
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#1Chang-Lung LeeH-Index: 17
#2A. WrightH-Index: 2
Last. Lixia LuoH-Index: 9
view all 15 authors...
Delayed radiation myelopathy is a rare, but significant late side effect from radiation therapy that can lead to paralysis. The cellular and molecular mechanisms leading to delayed radiation myelopathy are not completely understood but may be a consequence of damage to oligodendrocyte progenitor cells and vascular endothelial cells. Here, we aimed to determine the contribution of endothelial cell damage to the development of radiation-induced spinal cord injury using a genetically defined mouse ...
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#1Claude J. RogersH-Index: 15
Last. Naresh MenonH-Index: 3
view all 8 authors...
A radiological/nuclear (RAD-NUC) incident, especially in an urban setting, results in diverse radiation-induced injuries due to heterogeneities in dose, the extent of partial-body shielding, human biodiversity and pre-existing health conditions. For example, acute radiation syndrome (ARS) can result in death within days to weeks of exposure to 0.7-10 Gy doses and is associated with destruction of the bone marrow, known as hematopoietic ARS (H-ARS). However, partial-body shielding that spares a p...
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#1Michaela R. Hoffmeyer (MRIGlobal)
#2Kristin Gillis (ASU: Arizona State University)H-Index: 1
Last. Joshua LaBaer (ASU: Arizona State University)H-Index: 55
view all 5 authors...
There is an unmet need to provide medical personnel with a Food and Drug Administration (FDA)-approved biodosimetry method for quantifying individualized absorbed dose response to inform treatment decisions for a very large patient population potentially exposed to ionizing radiation in the event of a nuclear incident. Validation of biodosimetry devices requires comparison of absorbed dose estimates to delivered dose as an indication of accuracy; however, comparison to delivered dose does not ac...
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#1Merriline Satyamitra (HHS: United States Department of Health and Human Services)H-Index: 1
#2Francisca Reyes Turcu (CDRH: Center for Devices and Radiological Health)H-Index: 3
Last. Lynne Wathen (Office of the Assistant Secretary for Preparedness and Response)H-Index: 3
view all 4 authors...
The public health and medical response to a radiological or nuclear incident requires the capability to sort, assess, treat, triage and ultimately discharge, as well as to refer or transport people to their next step in medical care. The Public Health Emergency Medical Countermeasures Enterprise (PHEMCE), directed by the U.S. Department of Health and Human Services (HHS), facilitates a comprehensive, multi-agency effort to develop and deploy radiation biodosimetry tests. Within HHS, discovery an...
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