Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

Published on Jan 24, 2013in Respiratory Research3.924
· DOI :10.1186/1465-9921-14-8
Hikari Koga8
Estimated H-index: 8
(Okayama University),
Nobuaki Miyahara33
Estimated H-index: 33
(Okayama University)
+ 8 AuthorsArihiko Kanehiro25
Estimated H-index: 25
(Okayama University)
Sources
Abstract
Background Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway responses is not well defined. In this study, we have investigated the impact of neutrophil elastase inhibition on the development of allergic airway inflammation and airway hyperresponsiveness (AHR) in previously sensitized and challenged mice.
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