Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?

•ATP-binding cassette (ABC) transporters are expressed in the hair follicle. •ABC transporter substrates include chemotherapy drugs that cause hair loss. •Targeted upregulation of these transporters may augment drug-induced alopecia. •Topical application via nanoparticle carrier systems would minimize systemic impact. Currently, efficacious treatments for chemotherapy-induced alopecia (hair loss) are lacking, and incidences of permanent hair...