Clinicopathological significance of claudin-4 in gastric carcinoma

Background Aberrant expression of claudin proteins has been reported in a variety of cancers. Previous studies have demonstrated that overexpression of claudin may promote tumorigenesis and metastasis through increased invasion and survival of tumor cells. However, the prognostic significance of claudin-4 in gastric cancer remains unclear. Methods Immunohistochemistry was used to analyze the expression of claudin-4 in 329 clinical gastric cancer...