Original paper

Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial

Volume: 381, Issue: 9865, Pages: 451 - 460
Published: Feb 1, 2013
Abstract
Rheumatoid arthritis is a heterogeneous chronic disease, and no therapeutic agent has been identified which is universally and persistently effective in all patients. We investigated the effectiveness of tofacitinib (CP-690,550), a novel oral Janus kinase inhibitor, as a targeted immunomodulator and disease-modifying therapy for rheumatoid arthritis.We did a 6-month, double-blind, parallel-group phase 3 study at 82 centres in 13 countries,...
Paper Details
Title
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial
Published Date
Feb 1, 2013
Journal
Volume
381
Issue
9865
Pages
451 - 460
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