Original paper
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
Abstract
Apoptotic cell death is a hallmark of the loss of insulin-producing beta cells in all forms of diabetes mellitus. Current treatments fail to halt the decline in functional beta cell mass, and strategies to prevent beta cell apoptosis and dysfunction are urgently needed. Here, we identified mammalian sterile 20-like kinase-1 (MST1) as a critical regulator of apoptotic beta cell death and function. Under diabetogenic conditions, MST1 was strongly...
Paper Details
Title
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
Published Date
Mar 16, 2014
Journal
Volume
20
Issue
4
Pages
385 - 397
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Notes
History