Vinculin network–mediated cytoskeletal remodeling regulates contractile function in the aging heart
Abstract
The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging heart remains elusive. We present the cardiac proteomes of young and old rhesus monkeys and rats, from which we show that certain age-associated remodeling events within the cardiomyocyte cytoskeleton...
Paper Details
Title
Vinculin network–mediated cytoskeletal remodeling regulates contractile function in the aging heart
Published Date
Jun 17, 2015
Volume
7
Issue
292
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