Original paper
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis
Abstract
Defective autophagy is implicated in the pathogenesis of nonalcoholic fatty liver diseases (NAFLD) through poorly defined mechanisms. Cardiolipin is a mitochondrial phospholipid required for bioenergetics and mitophagy from yeast to mammals. Here we investigated a role for ALCAT1 in the development of NAFLD. ALCAT1 is a lysocardiolipin acyltransferase that catalyzes pathological cardiolipin remodeling in several aging‐related diseases. We show...
Paper Details
Title
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis
Published Date
Jan 20, 2015
Journal
Volume
61
Issue
2
Pages
486 - 496
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Notes
History