IL-17/Th17 mediated synovial inflammation is IL-22 independent

Although a heterozygous deficiency of either complement component C4A or C4B is common, and each has a frequency of ∼20% in a Caucasian population, complete deficiencies of both C4A and C4B proteins are extremely rare. In this paper the clinical courses for seven complete C4 deficiency patients are described in detail, and the molecular defects for complete C4 deficiencies are elucidated. Three patients with homozygous HLA A24 Cw7 B38...